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Not a single day off sick, in fact I felt ridiculously good while taking Harvoni. Focused and full of energy. Just felt damn good.
I am twice as old as you, you should do it easy.

Either choice Sofosbuvir + Ledipasvir (Harvoni) or Sofosbuvir + Daclatasvir (Sovaldi + Daklinza) is good.

I don't have a strong preference but suspect Sofosbuvir + Daclatasvir has a slight edge in terms of both SVR and less side effects.

Some patients on Harvoni do seem to go a bit flat and low on energy 6-8 weeks into treatment.

Most of the side effects - headache and insomnia - are caused by Sofosbuvir in the ~ 20% of patients that get them. You have to have that.

Both should see you cured, and because side effects are relatively rare, and very individual it's often other things that help decide. Daclatasvir mixes well with almost all HIV drugs, and Harvoni is not great for patients with reflux/heartburn taking medication.

So in this case, what is your suggestion ? Which treatment is more appropriate for me ?
Fibrosis: F1-F2
ALT: 125, 15
Naive
Genotype: 1b
VL: between 1.000.000-1.200.000

Thank you !

Hi Bogdan 16, Our stomachs have plenty of acid to aid absorption so long as you do not take other drugs that interfere with that. The human stomach is a naturally low pH environment. If you are concerned about other drugs you are taking that could interfere with absorption then use this Liverpool site to check them:
www.hep-druginteractions.org/checker

Our good Dr Freeman has given you good advice "Either choice Sosofbuvir + Ledipasvir (Harvoni) or Sofosbuvir + Daclatasvir (Solvadi + Daclinza) is good.".

Hi Bogdan 16, It was the old Interferon treatments that made people feel too sick to work. We are lucky the DAA drugs are trouble-free, most of us who are on them can play and work as usual throughout treatment.
Best wishes for deciding which treatment will be best to treat your type1. I too found it hard to decide, but you are lucky because you have received good advice from Gaj and Dr James Freeman.

Hi Mnem,

Yes, I have read about interferon treatments and thank God now we have all this new treatments with less side effects and a higher rate of healing . I think I'm gonna go with Sovaldi though.

Best wishes with your treatment, Mnem.

Hi Bogdan 16, If you go with Solvadi then you will need to take it together with Daclinza to make it effective. Sofosbuvir + Daclatasvir (Solvadi + Daclinza). You need the combination to be cured

Yes

REDEMPTION 2 eTrial - generic Sovaldi® (Sofosbuvir 400 mg) and Daklinza® (Daclatasvir 60 gm)
REDEMPTION 3 eTrial - generic Harvoni® (Sofosbuvir 400 mg / Ledipasvir 90 mg)
REDEMPTION 4 eTrial - generic Epclusa® (Sofosbuvir 400 mg / Velpatasvir 100 mg)

Hi Bogdan,

Congratulations on pursuing treatment. As others have mentioned the side effects for these medications are generally mild. That's not to say that people haven't experienced them to a greater or lesser degree. Generally they seem to involve headaches, fatigue and insomnia (sometimes related ofcourse) but it would be unusual for them to affect your ability to work. The key seems to be to focus a little on your general health, eat well, drink lots of water and try to rest when possible.

Good luck Bogdan.