OK, promised I would update this thread with my personal experiences. So here goes.
Chlorcyclizine is stinky. When I removed the first pill from the blister pack the smell was sort of surprising.
Started clorcyclizine mid last week in addition to ongoing DAA treatment. This was around the time I had blood drawn for 8 week labs.
The starting dose was one 25mg tab at 8 hour intervals during the day, and a nightime dose of 50mg for a total of 100mg (or 2/3 of the trial dosage referenced in previous posts).
By Sunday I had cycled up to 150mg per day. This IS a big 24hr dose. By late afternoon I realized there was so much of the stuff in my system I could actually taste it (tastes like it smells), and decided to immediately scale back. Aside from the taste, the sedative effect was also noticeable. Was still fully functional, but glad I chose a weekend to try the 150mg dose. My personal impression is that the 150mg dose was too much.
So Sunday night, scaled back the nighly 75mg dose to 50mg, and broke a 25mg tab in half for the 8:00 AM, and 4:00 PM doses (12.5mg each).
Its Tues. and the 50mg dose at night and two 12.5mg doses during the day seem to work well for me. The nightly dose seems to help a little with sleep, and the two 12.5mg doses during the day are theoretically large enough to maintain decent serum levels, but don't seem to have the sedative effects of the larger doses.
The math for my dosing works out like this. 8:00AM 12.5mg + 4:00PM 12.5mg + 10:00 PM 50mg = 75mg per 24 hour period. So overall - the same maximum recommended dose (75mg per 24 hour period) as hay fever.
Right now I am planning to continue at this dose until 2 weeks past Sofosbuvir/Ledispavir DAA EOT. So EOT + 2 Weeks. Might stay on another couple of weeks (or longer) past that. Just haven't decided yet.
NOT recommending this to ANYONE. Simply reporting my own experience.
Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!