new Cochrane review - Hepatitis C: the key questions answered
I find it staggering that the Cochrane researchers even came up with the idea that the question of long-term benefit could possibly be addressed by looking at short-term studies specifically designed to look at a different question.
In our first group of patients, there was only one, who asked (and got) his medications without the added expense of individual testing. I worryed about that for 2 weeks until he called up and said:
"Hey Doc, you don't have to worry about these medications"
I said "How's that?"
He said, "It used to be after a morning on the tools I'd have to take a nanna nap"
[He was a bricklayer and could only manage a morning's work before he had to have a sleep] (Translation from Australian slang)
Then he said, "Now I can go all day. It's like I'm 20 years younger. One of the young fellas even came up to me and asked 'Hey boss, what are you taking, can I get the connection?' I told him 'Not those kinda drugs mate'"
So while there are some patients who don't see fantastic improvements, and there are some patients that get side effects, in my experience the results of treatment are so clear cut you read the Cochrane thing and go "WTF are you guys smoking?"
YMMV
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- Greedfighter
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And then there is this,
www.aidsmap.com/Hepatitis-C-virus-reinfe...h-DAAs/page/3139853/ by research scientists, undermining the Cochrane review.....maybe the Cochrane review could investigate good barbecue recipes, I am curious what is effective.
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
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The Guardian have at least had the decency to publish several contrary letters:
www.theguardian.com/society/2017/jun/13/...-drugs-are-effective
YMMV
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Professor Ed Gane chimes in:
www.nzdoctor.co.nz/news/2017/june-2017/1...0%99-a-misnomer.aspx
YMMV
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Prof Ed Gane is reported here
medicalhealthnews.net/cochrane-comes-dow...-39cure39-a-misnomer
G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!
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A response from the AASLD:
and
www.aasld.org/about-aasld/press-room/aas...cochrane-review-daas
Edit: EASL have also responded along similar lines:
www.journal-of-hepatology.eu/pb/assets/r...chraneEASLJMP003.pdf
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND



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As a scientist you're not allowed to say excatly what you mean, which could probably be contructed from the following words
ass
from
you
your
elbow
don't
know
YMMV
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