emo new Cochrane review - Hepatitis C: the key questions answered

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5 years 2 months ago #24803

I find it staggering that the Cochrane researchers even came up with the idea that the question of long-term benefit could possibly be addressed by looking at short-term studies specifically designed to look at a different question.

In our first group of patients, there was only one, who asked (and got) his medications without the added expense of individual testing. I worryed about that for 2 weeks until he called up and said:

"Hey Doc, you don't have to worry about these medications"

I said "How's that?"

He said, "It used to be after a morning on the tools I'd have to take a nanna nap"

[He was a bricklayer and could only manage a morning's work before he had to have a sleep] (Translation from Australian slang)

Then he said, "Now I can go all day. It's like I'm 20 years younger. One of the young fellas even came up to me and asked 'Hey boss, what are you taking, can I get the connection?' I told him 'Not those kinda drugs mate'"

So while there are some patients who don't see fantastic improvements, and there are some patients that get side effects, in my experience the results of treatment are so clear cut you read the Cochrane thing and go "WTF are you guys smoking?"


YMMV
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5 years 2 months ago #24806

And then there is this, www.aidsmap.com/Hepatitis-C-virus-reinfe...h-DAAs/page/3139853/ by research scientists, undermining the Cochrane review.....maybe the Cochrane review could investigate good barbecue recipes, I am curious what is effective. :lol: :lol: :woohoo: :cheer: :-1:


Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
Last Edit: 5 years 2 months ago by Greedfighter.
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5 years 2 months ago #24807

The Guardian have at least had the decency to publish several contrary letters:

www.theguardian.com/society/2017/jun/13/...-drugs-are-effective


YMMV
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5 years 2 months ago #24808
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  • Mnem
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  • Too many lives go into the making of just one. - Montale
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5 years 2 months ago #24809

G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!
Last Edit: 5 years 2 months ago by Gaj. Reason: ;-)
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5 years 1 month ago #24890

A response from the AASLD:

AASLD and IDSA would like to express our serious concerns regarding the recent Cochrane Group Review concluding that there is a lack of valid evidence supporting the benefit of direct acting antiviral (DAA) therapy for chronic infection with hepatitis C virus (HCV), and its supposition: “the possibility of potentially harming people with chronic hepatitis ought to be considered before treating people with hepatitis C with DAAs.” Our review of this Cochrane publication suggests significant flaws in this analysis, yielding a misleading and a harmful conclusion.

and

......even early data from the DAA experience support clear improvements in clinical outcomes that can be measured in the short term. Cure of HCV infection immediately reduces symptoms and organ dysfunction from severe extrahepatic manifestations including cryoglobulinemic vasculitis, a complication affecting up to 10 percent of HCV-infected patients.

www.aasld.org/about-aasld/press-room/aas...cochrane-review-daas


Edit: EASL have also responded along similar lines:
"EASL, the European Association for the Study of the Liver, one of the world leading associations of liver specialists, feels compelled to express its serious concerns after the recent publication of a Cochrane Group systematic review entitled “Direct acting antivirals for chronic hepatitis C” by Jakobsen et al."

www.journal-of-hepatology.eu/pb/assets/r...chraneEASLJMP003.pdf


G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 5 years 1 month ago by Gaj.
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5 years 1 month ago #24893

As a scientist you're not allowed to say excatly what you mean, which could probably be contructed from the following words

ass
from
you
your
elbow
don't
know


YMMV
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