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FDA Safety announcement AbbVie V Pak 8 years 6 months ago #1627
| www.fda.gov/Drugs/DrugSafety/ucm468634.htm Strangely, my instincts told me not to consider this treatment. Seems rather a jumbled mix of quite a few meds to me which must be a strain on the liver. The irony is, there is a warning of 'severe liver damage' with this treatment. Call me ignorant, but aren't these treatments supposed to be trying to prevent that very thing as part of the intention? GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC |
FDA Safety announcement AbbVie V Pak 8 years 6 months ago #1629
| The AbbVie trials are batting 100% I believe , my brother in law just finishing 27 weeks on it next week his sfx weren't too bad considering he was quite sick when he started. Gen 3a Started Sof Dac 16/10/15 V/L 20 Mill + Hep C pos approx. 27 yrs Non responder 2011 BMS (dac) Peg Rib |
FDA Safety announcement AbbVie V Pak 8 years 6 months ago #1667
Most drugs are metabolised by the liver. Even something as routine as Paracetamol/Acetaminophen can be liver toxic - while 2 x 500 mg four times a day is safe, if you take all 20 at once there is a good chance you get liver failure. So as a rule of thumb many medications are liver toxic at high doses - in effect the liver can not process them fast enough and toxic products build up. A number of promising drugs across many areas have failed in Phase 2/3 trials when patient have got liver failure from them. YMMV | |
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