×

Notice

The forum is in read only mode.
Welcome, Guest
Username: Password: Remember me
  • Page:
  • 1
  • 2

TOPIC:

Prof Ed Gane on Nine to Noon NZ 6 years 11 months ago #10014

  • emilio
  • emilio's Avatar
  • Offline
  • Moderator
  • Moderator
  • In the field of opportunity its ploughing time
  • Posts: 382
  • Karma: 8
  • Thank you received: 475
Just wondering does the Professor have any affiliation with the gilead sof/vel trials ocurring in NZ at present? Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

Prof Ed Gane on Nine to Noon NZ 6 years 11 months ago #10016

When something like this pops up, I think "agenda". Then the next thing that comes to mind is money and timing.

www.gastrojournal.org/article/S0016-5085(13)01653-3/abstract

This in particular:

Conflicts of interest The authors disclose the following: Edward J. Gane has received grants and done research for Gilead, served on the advisory boards of AbbVie, Boehringer Ingelheim, Gilead, Janssen, Novartis, Roche, Tibotec; has been a speaker for Gilead, Novartis, Roche, Tibotec; has patents with Gilead. Catherine A. Stedman has received grants and done research for Gilead; served on the advisory boards of Janssen and Roche. Robert H. Hyland, Xiao Ding, Evguenia Svarovskaia, G. Mani Subramanian, William T. Symonds, John G. McHutchison, and Phillip S. Pang are current employees of Gilead Sciences.

Funding This trial was supported by Gilead Sciences .


M
This email address is being protected from spambots. You need JavaScript enabled to view it.
forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
The following user(s) said Thank You: Ariel

Prof Ed Gane on Nine to Noon NZ 6 years 11 months ago #10017

  • Chapel
  • Chapel's Avatar Topic Author
  • Offline
  • Premium Member
  • Premium Member
  • Posts: 122
  • Karma: 2
  • Thank you received: 132
Whoa, did anyone expect a specialist involved in establishing DAAs in early trials would not have links to the DAA owner? Please shoot down the chemistry.

www.tvnz.co.nz/one-news/new-zealand/kiwi...-c-treatment-6177634
M, 57, Live in Wellington,NZ.
Genotype 1a diagnosed in 2013.
Treating for the first time since October 31 with Buyers Club Sof/Led. Thanks so much guys. Minimal side effects apart from sore throat at the start..
Viral load 5.4m when treatment started, Undetected at 4 weeks, 8 weeks, End of Treatment and 12-weeks post EOT. Yay!

Prof Ed Gane on Nine to Noon NZ 6 years 11 months ago #10028

  • emilio
  • emilio's Avatar
  • Offline
  • Moderator
  • Moderator
  • In the field of opportunity its ploughing time
  • Posts: 382
  • Karma: 8
  • Thank you received: 475
Thanks M, I thought as much! Follow money always!

What's that saying from Keating and Lange 'in a 2 horse race, always back self interest because at least you know it's trying'. Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.
The following user(s) said Thank You: mgalbrai, Ariel

Prof Ed Gane on Nine to Noon NZ 6 years 11 months ago #10031

"Actually, I wish someone would just shoot down Prof Gane's science". What science? Have they actually tested the meds? It doesn't seem like it.
HCV 35 yrs G1a F3 Tx naive
started Lesovir-C 15/12/2015
pre tx: VL 5,250,000 ALT 374 AST 208
FIBROSCORE 10.4

4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL
8 weeks tx ALT 29/ AST 34. VL UND
4 weeks after tx UND. SVR4. ALT 24/AST 18

Prof Ed Gane on Nine to Noon NZ 6 years 11 months ago #10032

  • Gaj
  • Gaj's Avatar
  • Offline
  • Moderator
  • Moderator
  • Optimist :-)
  • Posts: 1436
  • Karma: 32
  • Thank you received: 3082
Prof Gane has been involved in many/most of the DAA trials in NZ and not just involving the company that makes Velpatasvir.....and at least two of the leading specialists in Aust have been involved in this country's arms of the various phase trials for that drug. Same for U.S., Europe et al.

To some extent this comes down to whether we want to built a big wall between our medical specialists and Big Pharma. Do we want the Pharmas and their molecular chemists to just develop drugs on their own or do we want the safeguards and benefits provided when leading medical specialists have input into the design and approval process. And how do we avoid blatant self interest if the latter?

Well one way is via the Potential Conflict of Interest statement as quoted by mgalbrai. It is unfortunate that one of those was not included with the radio interview but good luck with that in regard to any of the public media outlets!

OTOH he participated in the interview along with Dr Freeman and while he provided what some may see as the "company line" and others a cautious medical establishment approach, he also supported supply chain integrity and did not make the connection between potential issues he foresaw and FixHepC sourced generics. That was done by members here.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
The following user(s) said Thank You: Vororo, pat1, Tina-Hill-facebook, Hazel

Prof Ed Gane on Nine to Noon NZ 6 years 11 months ago #10033

Dr Freeman says Prof Gane is one of the good guys and I am trying to respect that but in my view the bias from the Hepatitis Foundation goes beyond being cautious and conservative.
From www.hepatitisfoundation.org.nz/index.php...ndation-new-zealand/:
"are looking at importing generic versions of these drugs from overseas. Although this is not strictly illegal provided that that person has a prescription from a registered medical practitioner"
To which I respond "yes your bias does look huge in that, trying changing into 'importing generic versions of drugs from overseas is legal as long as you have a prescription'
It goes on to say "HFNZ would recommend that anyone considering importing generic drugs exercises caution and discusses the benefits and potential pitfalls with their hepatitis specialist prior to importation"
To which I respond "Good luck with that, my hepatitis specialist is playing the role of innocent bystander while FixHepC provided all the information and my GP does the work"
GT1 F4 compensated, I/F non-responder 1997
@2015-11-06 VL 3.5 x 10^6, started Twinvir
@2015-12-31 VL:UND
@2016-01-29 started 2nd 12 weeks of Twinvir
@2016-03-01 ALT=42 AST=42, other LFT in normal range

Prof Ed Gane on Nine to Noon NZ 6 years 11 months ago #10034

  • Hazel
  • Hazel's Avatar
  • Offline
  • Platinum Member
  • Platinum Member
  • Posts: 414
  • Karma: 39
  • Thank you received: 1699
Look, lots of interesting stuff but from within NZ, and Buyers Club, I'd like to say:

1) Prof. Ed Gane is an ally- not an enemy. The NZ Hep Foundation has been giving advice to people for over a month and anyone visiting any of their sites would have found their way here because of the prominence it has been given, from people who work there who care deeply about rapid access. If Prof Gane didn't approve of that, it would not stay up. It has. This is much better govt sponsored access to information than other countries have experienced. He said anyone who couldn't wait should look at generics, and directly congratulated Dr Freeman. In voicing his concerns, on RNZ, it gives him, as an advisor, more leverage when advising Pharmac to fund DAA's and get the best price. It is perhaps the unequal weight he gave to his concerns, rather than congratulations that has concerned people. Being interviewed live is difficult and it is easy to repeat one's important messages.

2) I too always want to know where the money comes and goes from, but it is, as noted, not possible for him to responsibly fill his position without running drug company sponsored trials.

3) Dr Freeman soaks up an enormous amount of pressure from all sides on our behalf, which isn't going to let up until the SVRs roll in. I don't think we should add to it- by showing our full confidence in him to manage the testing, the media, the medical support, trials, and everything else. This thread puts further pressure on him, to defend or respond- another burden he doesn't need from us. He has answered all of these things before, and speaks highly of Ed Gane in another thread.
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
The following user(s) said Thank You: DrJames, Archer, Chapel, Joy, Vororo, pat1, mgalbrai, Gaj, Lynne-Francis-facebook, Tina-Hill-facebook, IRMA88

Prof Ed Gane on Nine to Noon NZ 6 years 11 months ago #10041

  • DrJames
  • DrJames's Avatar
  • Offline
  • Platinum Member
  • Platinum Member
  • Posts: 1980
  • Karma: 111
  • Thank you received: 7263

Whoa, did anyone expect a specialist involved in establishing DAAs in early trials would not have links to the DAA owner? Please shoot down the chemistry.


Yes, I totally agree. Please could everyone play the ball not the man.

It would be virtually impossible to find high profile specialist in HCV who has not done work for one or more of the companies. To describe Prof Gane as eminent would be an understatement. Guru would be a better term.

If you read the disclosure carefully....

Edward J. Gane has received grants and done research for Gilead.... has patents with Gilead.

Try this Google query:

www.google.com.au/webhp?sourceid=chrome-...tent%20hepatitis%20c

And if you follow some of the citations you will find he was the lead author of the original Sofosbuvir trails when it was still with Pharmassett.

www.nejm.org/doi/full/10.1056/nejmoa1208953

His work is often cited "Edward J Gane et al"

The "et al" means "and other less distinguished researchers"
YMMV
The following user(s) said Thank You: Archer, Chapel, mgalbrai, CJ, Ariel, Gaj, Lynne-Francis-facebook, Tina-Hill-facebook, Hazel
  • Page:
  • 1
  • 2
Time to create page: 0.062 seconds

Copyright © 2015-2020 FixHepC

Back to Top