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Hep C and Me 6 years 8 months ago #7674

Hi Stew welcome to the forum another Westy like me. I hope it all goes well for you on treatment and if you have any issues don't hesitate to ask here but for the most part treatment on the orals is relatively smooth sailing.
Enjoy the ride.
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV

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Hep C and Me 6 years 8 months ago #7680

  • Jaz
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Best wishes for your Tx Stew! :)
3a F0 TX Naive
Started Tx 12/12/2015 Kingswood Sof/Dac

Pre Tx - ALT 71 AST 40 V/L 9 million
Day 11 - ALT 12 AST 15
4 week - LFTs normal - detected (same sample sent for v/l showed undetected) :/
6 week - UND
12 week EOT - UND
SVR4
SVR12

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Hep C and Me 6 years 8 months ago #7682

  • CJ
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Hi Stew,

Good luck with your tx.

Please take Dr James's advise, he knows what he's talking about, he's the expert.
If you feel you should talk to him there's a GP2U here on this forum.

Make an appointment & you can talk to him on the computer.
SKYPE's good.

Hope you get things sorted with the meds.

All the best,
Cindi x
J the young dragon slayer is:
HepC 1a since birth
Male aged 15
VL 2000000
Started Twinvir/ 10-11-15-then Sof/led.
NO sides so far !
after one week VL : 37
after 4 wks VL : UND !
EOT 2/2/16 UND.!
4 wks. post tx results....pending....
7/3/16 VL result : 4 week post tx: SVR !
12 weeks SVR !
24 wks SVR yeeaa!!
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Hep C and Me 6 years 8 months ago #7697

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I was told I could take Nexium as long as I took it at the same time as I took the generic Harvoni. I was advised not to take Ursodeoxycholic Acid if possible as interaction is unknown, however my bile reflux is at a stage where it comes 1st in order of treatment.
I'll probably have bloods done after my 2nd week to see if the generic harvoni is working and if I need to drop the nexium which I maybe able to do as its only good for acid reflux - not so much my main problem - bile reflux.

Proton-pump inhibitor doses comparable to omeprazole 20 mg or lower can be administered simultaneously with HARVONI under fasted conditions - Gilead
Diagnosed Hep C 2013
Geno Type: 1a
Treatment: Naïve
Cirrhosis
F4
2015 GGT 227 AST 79 ALT 89 Platelets 88
2016 Treatment Generic Harvoni Finished 29 March 2016
GGT 30 AST 19 ALP 67 Platelets 91
Qualitative Test Results April 12
Hepatitis C NAT (NA): Not Detected
P.C.R Test for Hep C 4th July: Negative
Virus Free
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Last edit: by Stew-H.

Hep C and Me 6 years 8 months ago #7840

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All the best Stew, wishing you a great result and a smooth treatment I am Day 2 here :) Lots of us just starting out there is so much great support here have a good day :)
Gen 1a
Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas.
pre sof/led VL 240,000 Fibsc F0
Day 25 <30
Day 32 UND
Week 10 UND
EOT UND ALT11AST17GGT19
SVR4 UND ALT10 AST16 GGT13
SVR8 UND ALT <9 AST16 GGT15
SVR12 UND ALT14 AST19 GGT12 Bili 5
EOT +18 ALT13 AST20 GGT9 Bili 5
EOT +21 ALT11AST15
Cured SVR12
Dysplasia Adenomas RemvdAug '16
SVR24 UND ALT11AST16
ColonoscopyClear Nov17
LumpectomyClear ‘18
LithotripsyCytoscopyBiopsy 4/18
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Hep C and Me 6 years 8 months ago #7935

  • Sirchinenge
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I took nexium all the way through treatment when ever I felt like it I don't recall anyone saying
it had to be taken at the same time it had no impact on my outcome.

Any research I have seen suggests there is no contradiction between them at least none I am
aware of.
Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.

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Hep C and Me 6 years 8 months ago #7937

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Hi Sir, I think the Dac you're on is okay but Led is a potential issue due to it needing a more acidic stomach environment to be absorbed properly?
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:

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Hep C and Me 6 years 8 months ago #7947

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You learn something new every day!

I'm starting haravoni next week I guess Ill be have to ask about the Nexium when I talk
to my Dr, good to know though.
Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.

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Hep C and Me 6 years 8 months ago #7963

  • Stew-H
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Didn't your last treatment work?
Diagnosed Hep C 2013
Geno Type: 1a
Treatment: Naïve
Cirrhosis
F4
2015 GGT 227 AST 79 ALT 89 Platelets 88
2016 Treatment Generic Harvoni Finished 29 March 2016
GGT 30 AST 19 ALP 67 Platelets 91
Qualitative Test Results April 12
Hepatitis C NAT (NA): Not Detected
P.C.R Test for Hep C 4th July: Negative
Virus Free
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Hep C and Me 6 years 8 months ago #7968

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I just started Tx yesterday Sof/Dac and have been taking Nexium for a couple of years +. I told the Doc my list of meds when we had our consult and he said everything was fine. I take Nexium as soon as I wake because it's meant to be 1 hr before I eat. I took the Sof/Dac within around 1/2 hr after Nexium yesterday and today. Seems fine so far.

Good Luck Stew :)
QLD Australia ☀️
G3a HCV 35 yrs Tx naive
Started Sof/Dac 13/01/16

Dec '15
AST 70
ALT 89
GGT 124
Fibroscore 8.5
F1-F2
13 Feb'16 VL UND #woohoo!
AST 24
ALT 26
GGT 50H
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Hep C and Me 6 years 8 months ago #8000

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I think the problem mainly deals with those who take Ledipasvir - so you should be ok taking nexium.
Diagnosed Hep C 2013
Geno Type: 1a
Treatment: Naïve
Cirrhosis
F4
2015 GGT 227 AST 79 ALT 89 Platelets 88
2016 Treatment Generic Harvoni Finished 29 March 2016
GGT 30 AST 19 ALP 67 Platelets 91
Qualitative Test Results April 12
Hepatitis C NAT (NA): Not Detected
P.C.R Test for Hep C 4th July: Negative
Virus Free
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Hep C and Me 6 years 8 months ago #8663

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Week 3 has arrived - so far - so good.
I stopped taking Nexium after the 1st week as I was diagnosed with bile reflux - not acid reflux so my GP put me on Ursodeoxycholic acid - for the treatment of bile reflux gastritis. It seems to be working except I still wake around 2am with fevers, burning sensations, sweats and heart palpitation. My GP is not sure whether its due to bile reflux, hep C or ulcerative colitis. My GP suggested increasing the Ursodeoxycholic acid to see if it helps any.
Off to the liver clinic tomorrow for my first visit since starting treatment.
Diagnosed Hep C 2013
Geno Type: 1a
Treatment: Naïve
Cirrhosis
F4
2015 GGT 227 AST 79 ALT 89 Platelets 88
2016 Treatment Generic Harvoni Finished 29 March 2016
GGT 30 AST 19 ALP 67 Platelets 91
Qualitative Test Results April 12
Hepatitis C NAT (NA): Not Detected
P.C.R Test for Hep C 4th July: Negative
Virus Free
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Hep C and Me 6 years 8 months ago #9313

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Three weeks in and I have my LFT's. It seems generic harvoni is working.
Before GGT227
Now GGT 88
Before AST 79
Now AST 20
Before ALT 89
Now ALT 12
So there has been a significant improvement in my liver enzymes. This hopefully will prevent further cirrhosis of my liver.
Still feel lousy and wake every night with fevers, heart palpitations, sweats and abdo pain, although not as bad as before. I guess these could be contributed to other problems I have caused by cirrhosis of the liver.
Diagnosed Hep C 2013
Geno Type: 1a
Treatment: Naïve
Cirrhosis
F4
2015 GGT 227 AST 79 ALT 89 Platelets 88
2016 Treatment Generic Harvoni Finished 29 March 2016
GGT 30 AST 19 ALP 67 Platelets 91
Qualitative Test Results April 12
Hepatitis C NAT (NA): Not Detected
P.C.R Test for Hep C 4th July: Negative
Virus Free
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Hep C and Me 6 years 8 months ago #9316

Awesome!
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
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Hep C and Me 6 years 8 months ago #9318

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Hi Stew,

Good changes in your LFTs! Less inflammation means less damage being done. :)
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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