emo SVR?

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6 years 8 months ago #1474

Hi,
Is there any proof of SVR on any of the generics yet?
Also are the generics bio similar to the licenced orals?
Thanks,
Cindi x


J the young dragon slayer is:
HepC 1a since birth
Male aged 15
VL 2000000
Started Twinvir/ 10-11-15-then Sof/led.
NO sides so far !
after one week VL : 37
after 4 wks VL : UND !
EOT 2/2/16 UND.!
4 wks. post tx results....pending....
7/3/16 VL result : 4 week post tx: SVR !
12 weeks SVR !
24 wks SVR yeeaa!!

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6 years 8 months ago #1489

CJ wrote:

Hi,
Is there any proof of SVR on any of the generics yet?
Also are the generics bio similar to the licenced orals?
Thanks,
Cindi x

Have a good read here Cindi blogs.hepmag.com/gregjefferys/


cheers


Gen 3a Started Sof Dac 16/10/15
V/L 20 Mill +
Hep C pos approx. 27 yrs

Non responder 2011 BMS (dac) Peg Rib
The following user(s) said Thank You: CJ

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6 years 8 months ago #1501

Yes, there are patients at SVR4, SVR12 and one I know of at SVR24 (who sourced research APIs very early on)

I have over 100 patients on generics and all but 3 were VL = 0 at 4 weeks. One was VL = 0 at EOT and the other 2 are pending 6 week load testing (one with VL 47 @ 3.5/52, the other < 15)

Bioequivalence as in pharmacokinetic AUC testing is a cheap hack to avoid doing actual trials when introducing generics.

The actual clinical results on these generics are in line with expectations.


YMMV
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