TOPIC:

Thanks for that link Miko3, a different trial to previously mentioned but interesting initial results especially considering decompensated liver disease and what look to be relatively mild sides (Adverse Events). Do you know if SVR12 or 24 results have been published yet?

Ah, just saw Dr James comment on sim availability and hopefully that will change soon but think I'll keep going with current plan.

The reason I mentioned SOF Dac sim and not the other combos in that small trial was that SOF Dac sim did not have any slow responders. 6/6 was the original number. Ledipasvir combo had 6/12 pull out early and the other one had 2/8 pullout. That was how the 18 was made up. It seems clear Dac is superior to Ledipasvir In log kill and this imight be important in a three way short course.

Simeprevir is available on the PBS and I wonder of there is any caveat on just getting the script filled.

$37

Gaj I did some time ago try to find out if any followups were available.I emailed the Texas Liver Institute and got nowhere.I was hoping something might be presented at the AASLD conference.The important thing to realise is at normal prices the combination is totally impractical because the cost is getting up towards the cost of a liver Transplant..However,if you are talking generics it is an option that could well be investigated further,and I was more than willing to try it.I am wondering if Dr Freemans suggestion of using riba for only the last 12wks of a 24wk tx could also be replaced by using simeprevir for say the last few months if a generic source could ever be found.

Johnboy,I think you are mistaken that simeprevir is readily available on the PBS.My specialist showed me the restrictions and formfilling that he would have to go through to get it.One is that it has to be used in combination with Peg INF.Dr Freeman has posted these impossible restrictions elswhere.It is certainly not available on the PBS for use in combination with overseas aquired generics.

I know two people who got it on prescription from their chemists. They had to order it in.

They were written a script for Int/Rib but they did not fill that part of the script and took sofosbuvir from India instead,

Johnboy.We should be very grateful at the growing number of GP'S and Liver clinics that are supporting the use of generics.
But I cant believe any sane GP would be willing to monitor your tx with sim knowing how you got it.Nor have we any right to expect them to.
Much better a safe source of generic simeprevir that can be tested is found overseas.