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viral load test 8 years 4 months ago #6406
Hey! This is life! I had the same, first under 12 and afterwards under 30!!! I was freaking out! Now undetected...don't worry!
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viral load test 8 years 4 months ago #6408
| Doh - I kinda 'got' the VL testing thing, but now I'm all confused again ! Will ask for the simple version again 4 weeks into treatment, to make sure GP does the right test & and so I can understand the results GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC |
viral load test 8 years 4 months ago #6410
Hi Jeanmarc, Any news from the lab? Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety. Started Twinvir 12/12/15. Two weeks ALT 17 at 2 weeks Viral Load UND at 2 weeks ALT 13.5 at 7 weeks EOT ALT 10.5 at 15 weeks EOT ALT 13 at 27 weeks EOT, VL UND, Cured | |
viral load test 8 years 4 months ago #6437
Hi so, yesterday I finally decided to go to Bangkok to consult a doctor and I also wanted to have some more exam ,like a fibroscan ... I went ,this morning ,to the Bangkok hospital ,one of the most recommended hospital of Thailand.I saw a doctor ,told him my story with the treatment by twinvir and show him my lab results and then with no hesitation he told me that these results mean a no detected and also that I don't need to spend money ,now, for more exam !He told me to wait the end of my treatment before to make a full check up . That's a good new! At the end ,the doctor asked me all information about the way I could get the twinvir in Bangladesh and told me he will recommend his patients to follow the same way !!! Thank everybody on this forum for your support The following user(s) said Thank You: klhilde, coral, Paul-Jarman-facebook, Lynne-Francis-facebook, sonix | |
viral load test 8 years 4 months ago #6439
| Thats good news Jeanmarc, yep wait till 12 weeks after finish treatment that should give you a good idea if it's gone then again @ 6 months. Two time relapser. SVR 4 achieved 12/16 at last SVR 12 achieved 22/02/2017 The Bastard has been defeated GT 3 - about 28 yrs with HCV |
viral load test 8 years 4 months ago #6441
So, to recap; 1. You should have a complete liver function test and RNA Quantitative just before beginning treatment. 2. You should have a complete liver function test and RNA Quantitative at around 2-4 weeks. 3. Then just an RNA Qualitative at say, EOT. 4. Then an RNA Qualitative at 12 weeks after EOT. 5. Then one more just to be sure at 24 weeks. Is this right? This email address is being protected from spambots. You need JavaScript enabled to view it. Genotype 3 VL 4,100,000 ALT 101 AST 71 Treatment Naive Started Sof/Dac Jan 12, 2016 VL= <15 4 weeks in. AST/ALT normal. VL=UNDETECTED 8 weeks in. SVR4= Virus back. 3,300,000 Started generic Epclusa Sep. 23, 2017 4 weeks in <15 *Detected. 12 weeks in <15 *Not Detected. 16 weeks in <15 *Not Detected. Finished 24 weeks treatment 3-17-18 SVR5 <15 Not Detected. SVR 20 <15 Not Detected. SVR 44 <15 Not Detected. Thank you Jesus. Thank you Dr. James | |
viral load test 8 years 4 months ago #6443
| I would skip the RNA Qualitative test , if your clear at 2-4 weeks should still be clear at EOT. Do the 12 and 24 week ones though. Two time relapser. SVR 4 achieved 12/16 at last SVR 12 achieved 22/02/2017 The Bastard has been defeated GT 3 - about 28 yrs with HCV The following user(s) said Thank You: Jimmy6429 |
viral load test 8 years 4 months ago #6445
Right on. This email address is being protected from spambots. You need JavaScript enabled to view it. Genotype 3 VL 4,100,000 ALT 101 AST 71 Treatment Naive Started Sof/Dac Jan 12, 2016 VL= <15 4 weeks in. AST/ALT normal. VL=UNDETECTED 8 weeks in. SVR4= Virus back. 3,300,000 Started generic Epclusa Sep. 23, 2017 4 weeks in <15 *Detected. 12 weeks in <15 *Not Detected. 16 weeks in <15 *Not Detected. Finished 24 weeks treatment 3-17-18 SVR5 <15 Not Detected. SVR 20 <15 Not Detected. SVR 44 <15 Not Detected. Thank you Jesus. Thank you Dr. James | |
viral load test 8 years 4 months ago #6452
Congratulations on achieving Undetected, jeanmarc! It must be a huge relief after all the worrying about what the tests meant! G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND | |
viral load test 8 years 4 months ago #6481
I told you Jeanmarc, The lab have saved the money by doing only quantitative. <12 means UND Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety. Started Twinvir 12/12/15. Two weeks ALT 17 at 2 weeks Viral Load UND at 2 weeks ALT 13.5 at 7 weeks EOT ALT 10.5 at 15 weeks EOT ALT 13 at 27 weeks EOT, VL UND, Cured The following user(s) said Thank You: jeanmarc | |
viral load test 8 years 3 months ago #7246
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I think he needs to have this looked at as best I know 12 suggests they can not say for sure you're undetected it simply means the virus is too low to quantify. I know, a chap who was 12 all the way through treatment at week 12 post treatment he was back detected. Id double check to be sure. Note; I thought prior to starting treatment everyone would be non detected by week 4 at the latest you can imagine I was some what taken a back to find out at week 5 plus I'd a VL of 17 therefore my chances are lower I will be UD by week 12. Gilead disregarded all VL testing during the trials for this reason. At week 2/4/6/8/10/12 if you're in the easy Geno types if you're UN not 12 UD you've a 99% chance six months post treatment you're cured. In fact at EOT 12 can turn out to be cured six months post treatment. But, if you're 12 all the way through its possible you need to extend treatment due to resistance,suggesting you're UD at 12 is not factual. My point is this not everyone clears at week 2 telling them the lab is wrong is not always factual or correct patients need to understand what these tests mean not what we think they mean. Sob/Dac from Oct 29 2015 Geno 1b Fiberscan 9.9 Pre treatment Fiberscan 7.4 week 10 VL 1.3 million pre treatment Week 2.5 VL 96 Week 5.5 VL 17 Week 10 VL UD SVR 3 UD SVR 16 UD Cured: All liver functions in normal ranges. |
viral load test 8 years 3 months ago #7257
The way I understand it, 'Quantitative' testing determines the actual number per ml of bloodborne virus. However, it is only accurate between 12 and 10,000,000. The 'Qualitative' testing is far more accurate, but can only determine present/not present. So you use quantitative to see how you're doing until <12, then do qualitative to see if it goes all the way down to undetected. (zero). Dr. Freeman? This email address is being protected from spambots. You need JavaScript enabled to view it. Genotype 3 VL 4,100,000 ALT 101 AST 71 Treatment Naive Started Sof/Dac Jan 12, 2016 VL= <15 4 weeks in. AST/ALT normal. VL=UNDETECTED 8 weeks in. SVR4= Virus back. 3,300,000 Started generic Epclusa Sep. 23, 2017 4 weeks in <15 *Detected. 12 weeks in <15 *Not Detected. 16 weeks in <15 *Not Detected. Finished 24 weeks treatment 3-17-18 SVR5 <15 Not Detected. SVR 20 <15 Not Detected. SVR 44 <15 Not Detected. Thank you Jesus. Thank you Dr. James The following user(s) said Thank You: isaing4 | |
viral load test 8 years 3 months ago #7340
I agree with Sirchinenge, But the labs should be more professional and give better interpretation by writing the words Detected or Undetected. Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety. Started Twinvir 12/12/15. Two weeks ALT 17 at 2 weeks Viral Load UND at 2 weeks ALT 13.5 at 7 weeks EOT ALT 10.5 at 15 weeks EOT ALT 13 at 27 weeks EOT, VL UND, Cured | |
viral load test 8 years 3 months ago #7414
Investigating many patients cured at others forums, being UND or < LLOQ (<15) is insignificant. Even patients that have been detected at EOT but < LLOQ have been cured. At the time of trials with Harvoni the LLOQ have been 25 IU/ml, now they have updated to 25 and 15. Other patients on Harvoni have been UND at 4 weeks and then detected at 6 weeks followed with UND at 8 weeks and still cured with three months treatment. From Gilead Page: HARVONI was administered once daily by mouth in these trials. For subjects who received ribavirin (RBV), the RBV dosage was 1000 mg per day for subjects weighing less than 75 kg or 1200 mg per day for subjects weighing at least 75 kg. RBV dose adjustments were performed according to the RBV labeling. Serum HCV RNA values were measured during the clinical trials using the COBAS TaqMan HCV test (version 2.0), for use with the High Pure System in ION-3, ION-1, ION-2, SIRIUS and ION-4 studies or the COBAS AmpliPrep/COBAS Taqman HCV test (version 2.0) in ELECTRON-2, and 1119. The COBAS TaqMan HCV test (version 2.0) for use with the High Pure System has a lower limit of quantification (LLOQ) of 25 IU per mL and the COBAS AmpliPrep/COBAS Taqman HCV test (version 2.0) has a LLOQ of 15 IU per mL. Sustained virologic response (SVR12) was the primary endpoint and was defined as HCV RNA less than LLOQ at 12 weeks after the cessation of treatment. Relapse was a secondary endpoint, which was defined as HCV RNA greater than or equal to LLOQ with 2 consecutive values or last available post-treatment measurement during the post-treatment period after achieving HCV RNA less than LLOQ at end of treatment. Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety. Started Twinvir 12/12/15. Two weeks ALT 17 at 2 weeks Viral Load UND at 2 weeks ALT 13.5 at 7 weeks EOT ALT 10.5 at 15 weeks EOT ALT 13 at 27 weeks EOT, VL UND, Cured | |
viral load test 8 years 3 months ago #10213
Hello just receive my test result of EOT by twinvir 3 months. This time is clearly written down NOT DETECTED I wish for everybody the best results thanks everybody on this forum for all those helpful support The following user(s) said Thank You: DrJames, Joy, LondonGirl, mgalbrai, Chejai, Gaj, Lynne-Francis-facebook, zhuk, isaing4, magpie | |
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