100% - Dare to Dream The Impossible Dream - FixHepC

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17 January 2016 at 10:12 am #9507
Dr James
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The combination of Sofosbuvir and Daclatasvir provided pangenotyic treatment of HVC by inhibiting NS5B and NS5A.

Simeprevir inhibits the NS3A/4 components: https://en.wikipedia.org/wiki/Simeprevir

If you’ve been wondering if inhibiting NS3A/4 + NS5A + NS5B might work really well consider the IMPACT study that was reported at the AASLD November 2015 meeting – 100% might well be here:

AASLD_IMPACTStudy.pdf

Before you get too excited there is no generic Simeprevir currently available and the cheapest price you might find it is for $7500 USD for 3×28 in Egypt, but it does look very promising.

Note that Simeprevir is not active against GT3 and you don’t want the Q80K mutation

http://www.ncbi.nlm.nih.gov/pubmed/22326470

http://www.ncbi.nlm.nih.gov/pubmed/19852962

http://www.ncbi.nlm.nih.gov/pubmed/26392483

YMMV
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