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  • 28 September 2018 at 6:42 am #28583
    Poodlelover
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    @poodlelover

    Hi Dr Freeman,

    I consulted with you before I began my treatment of sofosbuvir and daclatasvir for genotype 2, that I received from Greg. Anyhow, I did blood work after 10 weeks on these meds and I am happy to say I have cleared the virus. Of concern is my alkaline phosphatase went from 63 to 92. Should that be of concern?

    28 September 2018 at 12:48 pm #28586
    dope-on-a-rope.jpgDr James
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    @fixhepc

    Hello Poodlelover,

    While your Alk Phos is a bit higher it is still well below the 120 upper limit of normal, so it’s a normal value that raises no concern.

    Liver enzyme values can and do wander up and down.

    ALP is known to follow a diurnal variation pattern and oscillates 20% during the course of a single day.

    https://www.researchgate.net/publication/14103473_Diurnal_Variation_of_Bone_Mineral_Turnover_in_Elderly_Men_and_Women

    YMMV

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