Home Forums Main Forum Media & News Are New Drugs for Hepatitis C Safe? A Report Raises Concerns

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    avatar876.jpegGaj
    • Guardian Angel
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    @gaj

    Okay, so reading that paper more closely it appears that many of the cohort were from pre DAA treatments.

    Here is a more recent one looking only at DAAs.

    “Conclusion. Treatment of chronic HCV with DAAs leads to clinically relevant reduction in liver fibrosis over the first year post-treatment, measured by Fibroscan, even after controlling for elevated ALT”

    https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofw172.310/2636806/Direct-Acting-Antiviral-DAA-Therapy-for-Chronic

    The summary is that 51.1% had improved so far but that consisted of just those who improved by greater that 30% within the first 12 months of treatment and 57% of the cohort had “significant fibrosis” to begin with.

    It is still early days for DAA treatments to be followed up long term and over time I would expect larger cohort studies and better long term results. If you google something like “fibrosis regression after DAA treatment” there are other recent trials that reach similar conclusions and I didn’t see anyone attempting to claim what you have been told.


    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

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