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  • 3 January 2016 at 3:04 am #7853
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    The evidence that HCV causes demonstrable changes in patient’s brain aka “Brain Fog” is quite old:

    http://www.natap.org/2012/HCV/012712_02.htm

    http://www.natap.org/2013/HCV/081413_01.htm

    The pleasing thing is that it gets better with DAA treatment:

    http://hepatitiscnewdrugresearch.com/hcv-neuropsychiatric-symptoms-ldquobrain-fogrdquo.html

    Yes, it is in all your mind, and it is caused by real (reversible) pathological changes.

    YMMV

    3 January 2016 at 3:19 am #7856
    Avatar photoDebs
    • Guardian Angel
    • ★★★★★
    @debs

    Thank god for that! :)

    3 January 2016 at 3:28 am #7857
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    I’m with you there Debs – feels like you’ve lost x amount of IQ points, doesn’t it!

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    3 January 2016 at 3:42 am #7858
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    “—nothing would be more frightening to me than losing the ability to think clearly, retain information and/or have difficulty with trying to work on multiple tasks (to name a few) that affect your everyday life……..”

    This!!

    ……but thanks to you Doc and the rest of the FixHepC team, this is one of the most striking changes I am noticing after six weeks treatment. Still a long way to go but I no longer fear losing my ability to function independently.

    Thanks again
    G

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    3 January 2016 at 3:53 am #7861
    Avatar photoTina-Hill-facebook
    • Guardian Angel
    • ★★★★★
    @tina-hill-facebook

    I had no idea just how much HCV affected my train of thought and demeanour in general until I started treatment. Within a week of treatment I have found clarity of thought and I am much less irritable. I had no comprehension of just how much HCV was destroying me until I have begun to get better.

    SVR 24

    3 January 2016 at 3:56 am #7863
    Avatar photoDebs
    • Guardian Angel
    • ★★★★★
    @debs

    Definately Zhuk! Everyone seems to report starting to think more clearly whilst on treatment. It will be happening to you soon!

    3 January 2016 at 4:14 am #7865
    Avatar photosabrecat
    • Guardian Angel
    • ★★★★★
    @sabrecat

    This issue and the attached article may need some ‘placing in context’, at least in my point of view.

    I can relate to many feelings of fogginess and depression.

    I was treated for many years for depression after a bad time with my previous field of work (child protection) many years ago in the mid late 1990’s. I happened to work in an area that is challenging and people being off on ‘stress leave’ was common. HCV or work – who is to know?

    But since being infected, I have completed a second undergraduate degree, a Post Grad Certificate and Diploma, and in 2015 my Masters. I admit I found the later years hard going, but was it hard material, working at the time and eventually being crook with a HCC, age or simply HCV??

    I remember HCV featuring in renewing my Pilot Licence medical years back (as well as the depression) and fair enough; there were a few incidents in the USA of people flying into buildings (well before 9/11). I guess I get a bit cautious with Hep C and the risk people may make assumptions about me, but well and good if these assumptions don’t affect me in anyway.

    I think the main symptom of Hep C, in spite of claims it is the “unseen killer”, is the obvious fatigue we feel. For me, I am more sure then ever this is the case now I am being treated. Again, thanks for those with the foresight and actions to get us treated.

    Yours

    J.

    3 January 2016 at 4:16 am #7866
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Yes, it is in all your mind, and it is caused by real (reversible) pathological changes.

    Hey Dr F – Thank-you :cheer:
    You know, I always wonder why people belittle things by saying ‘It’s all in your mind”….I mean, your mind controls your body surely? and ‘due to pathological changes’ , as you say, changes causes physical symptoms – It all makes total sense to me !

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    3 January 2016 at 4:26 am #7869
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Thank God I had very patient bosses! I work for four Lawyers and have worked within the legal profession for over 43 years. At times I would just sit at my computer and know what I had to do but just couldn’t get the old brain to fire up to show me how to do it :)

    YMMV

    3 January 2016 at 4:54 am #7870
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk
    Debs wrote:

    Definately Zhuk! Everyone seems to report starting to think more clearly whilst on treatment. It will be happening to you soon!

    Fingers crossed yes Debs…its the feeling of being under a constant cloud, like you want to shake your head to disperse it, but can’t. As well as forgetting/not comprehending embarassing simple things/concepts sometimes. There have been moments before I knew that hep caused this issue when I wondered if I was on the cards for early-onset Alzheimers (my dad suffered from it) Thank god I know differently on that score now.

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    3 January 2016 at 4:47 pm #7887
    Avatar photoDebs
    • Guardian Angel
    • ★★★★★
    @debs

    Hi Zhuk, I totally relate to what you are saying. I was thinking maybe I had dementia or something! And my short term memory is terrible at times. Glad too see from your patient story that you are feeling you are thinking a bit clearer already! This is the bit I’m looking forward to. And not having the fatigue. You are winning that battle!

    3 January 2016 at 5:27 pm #7892
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    me too Debs! For me, it’s names of things, things I have always known – they sit on the tip of my tongue forever and just won’t come to me. Could be something as simple, such as an item, but worst, is names of people and places, obvious ones too. Drives me nuts. Often, I read back on what I have typed – It’s just really odd mistakes, I have never been a good typist, but whole words that sound similar by ear, get typed wrong…Can’t all be the auto-correct !

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    4 January 2016 at 5:08 am #7926
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Thanks Debs :) You and LG will be there soon too.

    Couldn’t agree more on forgetting the most obvious names for things…I remember holding a fork once and COULD NOT remember what the hell it was called lol Knew what it was for (good sign!) but no idea it was called “fork”, even after a lot of thought. Bit disturbing :P

    And calling people by the wrong names, even after you’ve know them for years…/mega facepalm lol

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    5 January 2016 at 4:53 pm #8041
    Avatar photomgalbrai
    • Guardian Angel
    • ★★★★★
    @mgalbrai

    http://youtu.be/vTHYHW-eWRo

    Curehcvnow@gmail.com
    http://forums.delphiforums.com/generichcvtx

    G 1a F-1
    Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
    11/17/15 4 wk lab ALT 17 AST 16 <15
    11/18/15 Started Harvoni
    12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
    1/14/16 Fin. Tx
    7/07/16 UND SVR 24

    5 January 2016 at 5:34 pm #8048
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    love it – mgalbrai – great ‘choon’

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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