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  • 18 October 2015 at 3:52 pm #2453
    Sir-Paul-Paul-MJ-twitter
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    • Acolyte
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    @sir-paul-paul-mj-twitter

    Is there any evidence to suggest ledispasvir combined with sof and dac may increase svr numbers ?

    Gen 3a Started Sof Dac 16/10/15
    V/L 20 Mill +
    Hep C pos approx. 27 yrs

    Non responder 2011 BMS (dac) Peg Rib

    19 October 2015 at 4:01 am #2469
    Avatar photoemilio
    • Guardian Angel
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    @emilio

    Hi Paul

    I’ve had this discussion with others including James and one would assume so, however, there has been no research on this whatsover, well I haven’t seen it. Both are NS5As so if we go with the theory of adding additional weapons then yes, however, will they counteract both or either?? We don’t know? What about using Dac for the first 6 weeks and then finishing with Led?? Someone will eventually try combo, but as Dylan said ‘it aint me’. Em

    19 October 2015 at 4:24 am #2471
    Johnboy
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    • Guardian Angel
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    @johnboy

    Can’t see the logic in using two NS5a inhibitors. Dac is the stronger of the two.

    G1 58yo F1 54,000 viral load Relapser 2003/4 Sof/Dac started 21/9/2015

    19 October 2015 at 5:05 am #2473
    Avatar photoemilio
    • Guardian Angel
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    @emilio

    Yep that’s right daclatasvir has a 3.5 kill log whilst ledipasvir has 3.0. Em

    19 October 2015 at 5:08 am #2474
    Sir-Paul-Paul-MJ-twitter
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    • Acolyte
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    @sir-paul-paul-mj-twitter
    emilio wrote:

    Hi Paul

    I’ve had this discussion with others including James and one would assume so, however, there has been no research on this whatsover, well I haven’t seen it. Both are NS5As so if we go with the theory of adding additional weapons then yes, however, will they counteract both or either?? We don’t know? What about using Dac for the first 6 weeks and then finishing with Led?? Someone will eventually try combo, but as Dylan said ‘it aint me’. Em

    It’s kind of like the nuclear option as far as I can see if i’m not SVR -0 @ 4 weeks or close to it I would add Rib as well. I don’t want to be doing this again. I was a non responder on a Dac trial in 2011 with Inf and Rib, Crash or crash through someone also said :)

    Gen 3a Started Sof Dac 16/10/15
    V/L 20 Mill +
    Hep C pos approx. 27 yrs

    Non responder 2011 BMS (dac) Peg Rib

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