Home › Forums › Main Forum › FixHepC Admin › Ledipasvir-sofosbuvir safe, effective for older HCV patients

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  • 5 April 2016 at 8:53 pm #14949
    Tommy
    • Guardian Angel
    • ★★★★★
    @tommy

    http://www.pharmacist.com/ledipasvir-sofosbuvir-safe-effective-older-hcv-patients

    A new study has found that a ledipasvir–sofosbuvir combination is safe and effective for older individuals with genotype 1 hepatitis C virus (HCV) infection.
    A new study has found that a ledipasvir–sofosbuvir combination is safe and effective for older individuals with genotype 1 hepatitis C virus (HCV) infection. Researchers analyzed sustained virological response at 12 weeks and monitored adverse events, comparing a sample of nearly 2,300 patients aged 65 years and older with a group younger than 65 years. At 12 weeks, 97% of the younger patients and 98% of those aged 65 years and older achieved sustained virological response. The most common adverse events were headache and fatigue. The findings are published in Hepatology.

    Reuters Health (03/22/16) Janeczko, Lorraine

    http://www.medscape.com/viewarticle/860594

    Genotype 1A
    ALT 473
    AST 226
    Virus Load 3,119,030
    Results as of May-2016
    5 week viral load/undetected as of 12/02/2016
    Liver Biopsy Results from Feb 2013
    Portal/Periportal chronic inflammation and mild interface hepatitis (Grade 2)
    Focal Lobular chronic inflammation (Grade 1)
    Portal/Periportal fibrosis (stage 1-2 trichrome and reticulin stains utilized)
    Negative Iron stains.

    6 April 2016 at 1:18 am #14954
    Avatar photoMichael-Henry-facebook
    • Topics: 9
    • Replies: 39
    • Total: 48
    • Recovery Champion
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    @michael-henry-facebook

    Hi Tommy,
    I’m 67 years old & today I just finished 168 days of Sofosbuvir / Ledisbovir , plus 84 days Ribavirin.
    I struggled with the Ribavirin side effects but just managed to stay on the full dose of 1200mg.
    The last 4 weeks of treatment I suffered a lot of joint & muscle pain.
    Also feeling fatigued most days.
    Now it’s a wait for SVR 4 & SVR 12 & SVR 24

    AUSTRALIAN
    HCV Genotype 1a
    2003 Relapsed Peg Interferon / Ribavirin
    Pre treatment VL 2,000,000
    ALT 65, AST 42, ALP 111, GGT 56
    Bridging F3-4
    Treatment -24 weeks – Sof , Led with 12 weeks Riba.
    4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14
    12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20
    24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14
    EOT 6th April 2016
    SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20

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