Mavyret and Kratom

This topic has 9 replies, 5 voices, and was last updated 5 years, 4 months ago by BrooklynBlizzard.

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26 March 2019 at 5:48 pm #29054
Gable65
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- Novice
@gable65
Hi I need to know of low doses of Kratom will effect my treatment on mavyret. I have genotype 3a and have a treatment period of 8 weeks. Please can anyone tell me if Kratom will interact with mavyret?? I have severe chronic back and joint pain but don’t want to ruin my chances of cure. Thank you
27 March 2019 at 4:51 am #29057
Mar
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- Guardian Angel
@mar
Hi Gable , welcome to the forum, and congratulations on starting treatment. Mavyret is a really excellent drug and you should be very optimistic about reaching cure. Regarding the use of Kratom with Mavyret, a previous answer by Dr James Freeman, FixHepC’s founder, on the forum states that Kratom should be avoided when treated with Daclatasvir medication, and that “it should be ok, but…” (so maybe best avoided) when treated with Epclusa medication, but he didn’t comment about Mavyret medication in that thread https://fixhepc.com/forum/drug-interactions/1519-sofosburvir-daclatasvir-worried-about-kratom-usage.html#26432 Hopefully he will provide his opinion about it here.

It’s worth noting though that the patient in the linked thread said “I felt so much better after finishing Epclusa I never bothered with kratom again”.

Making the world a better place – one patient at a time.
27 March 2019 at 12:18 pm #29059
Dr James
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@fixhepc
Hello Gable65,

While the strict answer is that “nobody knows” with respect to Kratom and Maviret it should be OK.

Both components of Maviret – glecaprevir and pribrentasvir – have what is called billary-faecal metabolism, which means (in English) they are excreted unchanged. As a result, they don’t have a metabolism in the body which could be impacted by most other drugs.

You should take your Maviret with a meal – it will improve the absorption of both these drugs.

https://www.drugbank.ca/drugs/DB13878
https://www.drugbank.ca/drugs/DB13879

YMMV
27 March 2019 at 12:34 pm #29060
Gable65
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@gable65
Thank you so much!!!
7 June 2019 at 7:12 pm #29252
Hopeful425
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- Acolyte
@hopeful425
Now I’m a little worried because I have used some Kratom during my mayvret treatment . I have two weeks left. Should I be concerned that I hindered my cure??
8 June 2019 at 5:02 am #29253
Mar
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@mar
Hi Hopeful, you shouldn’t be worried, Dr. James said above that it should be OK and gave good scientific reason for it. However, if I were you, I would probably stop Kratom for the remaining 2 weeks, just to be on the very safe side.

Making the world a better place – one patient at a time.
8 June 2019 at 2:37 pm #29256
Dr James
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@fixhepc
Hello Hopeful425 it should be ok, but I do tell my patients you can’t get problems from drugs you are not taking…

YMMV
3 July 2019 at 6:27 am #29297
BrooklynBlizzard
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@brooklynblizzard
With respect to your Kratom use during treatment, did it hinder it? Are you undetectable now? Also, how much were you using a day?
4 July 2019 at 7:57 pm #29303
Hopeful425
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@hopeful425
Hi Brooklyn!
I used about 2 tablespoons of kratom . I did however quit using it the last two weeks of treatment, and found that I felt significantly better without it.
My test reported unidentifiable !!
15 July 2019 at 9:31 am #29325
BrooklynBlizzard
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@brooklynblizzard
Congrats on you being undetectable! That’s great! So you only used 2 table spoons one time or regularly?

Thank for you reply.
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