Home › Forums › Main Forum › Experts Corner › Drug Interactions & Information › Sofosburvir + Daclatasvir Worried about KRATOM usage

  • This topic has 18 replies, 6 voices, and was last updated 2 years ago by Avatar photoMar.
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  • 18 June 2019 at 5:12 pm #29273
    Avatar photoMar
    • Guardian Angel
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    @mar

    Hi Christoffer, welcome to the forum, and congratulations on starting treatment with Epclusa, it’s a really great drug :+1: . Regarding the use of Kratom with Epclusa, a previous answer in this thread by Dr James Freeman, FixHepC’s founder, states that Kratom should be avoided when treated with Daclatasvir medication, and that “it should be ok, but…” (so maybe best avoided) when treated with Epclusa medication. He also said “I do tell my patients you can’t get problems from drugs you are not taking…”. So it’s probably wise to avoid it during treatment to eliminate any doubt. It’s also worth noting that the patient in this thread also said “I felt so much better after finishing Epclusa I never bothered with kratom again”.

    Making the world a better place – one patient at a time.

    19 June 2019 at 4:50 am #29274
    lamussa
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    • Novice
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    @lamussa

    Christoffer, stop the kratom now. Dr. James mentioned that kratom might increase levels of one of the active ingredients of Epclusa to toxic levels:

    It (kratom) is a potent inhibitor of a number of cytochromes including the CYP3A4 one that metabolised daclatasvir so would be expected to cause daclatasvir toxicity or increased side effects.

    Better not to use any herbal supplements while taking Epclusa unless approved by your treating physician.

    9 December 2022 at 7:33 pm #30218
    valesolove
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    • Novice
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    @valesolove

    Cheap Harvoni – https://onlinecheappills.com/harvoni.html I took harvoni for 3 months, missing only 1 dose which I made up quickly. No side effects at all. Tiredness was equal to tiredness prior to taking. I received my 2 month blood test after treatment & I AM CURED!!

    9 December 2022 at 8:47 pm #30219
    Avatar photoMar
    • Guardian Angel
    • ★★★★★
    @mar

    Hi valesolove, all the best with your treatment. Yes, the combination of Sofosbuvir + Daclatasvir is very effective. The majority of patients however experience mild side effects, so you’re one of the few people who experienced strong side effects unfortunately. Drinking a lot of fluids is a sure way to minimize side effects during treatment, so you may want to try that.

    Making the world a better place – one patient at a time.

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