SVR? - FixHepC

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20 October 2015 at 4:59 am #2528
Sir-Paul-Paul-MJ-twitter
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- Acolyte
@sir-paul-paul-mj-twitter
CJ wrote:

Hi,
Is there any proof of SVR on any of the generics yet?
Also are the generics bio similar to the licenced orals?
Thanks,
Cindi x

Have a good read here Cindi http://blogs.hepmag.com/gregjefferys/

cheers

Gen 3a Started Sof Dac 16/10/15
V/L 20 Mill +
Hep C pos approx. 27 yrs

Non responder 2011 BMS (dac) Peg Rib
20 October 2015 at 5:15 pm #2539
Dr James
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- Guardian Angel
@fixhepc
Yes, there are patients at SVR4, SVR12 and one I know of at SVR24 (who sourced research APIs very early on)

I have over 100 patients on generics and all but 3 were VL = 0 at 4 weeks. One was VL = 0 at EOT and the other 2 are pending 6 week load testing (one with VL 47 @ 3.5/52, the other < 15) Bioequivalence as in pharmacokinetic AUC testing is a cheap hack to avoid doing actual trials when introducing generics. The actual clinical results on these generics are in line with expectations.

YMMV
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