Hi TM,
Professor Ed Gane was curing people of Hep C before many people on the forum here even knew they had it!
What he has been trying to say in lay language is that Ledipasvir is a BCS class II medication with high permeability but poor solubility.
70% of all medications are BCS class II so the science and technology required to make them bioavailable (ie dissolve and get into the body) are well known. Really well known. Pharmacists were doing it before Gilead the company even existed.
We tested some of the very first Twinvir against Gilead medication from ION-1 and found it equivalent. While it is possible to make a bad generic Incepta do not.