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  • 26 February 2017 at 1:07 pm in reply to: Baseline VL below detection #25404
    1a2x
    • Topics: 1
    • Replies: 10
    • Total: 11
    • Acolyte
    • ★★
    @1a2x

    SVR 12 for me!

    Alt/Ast – 14/14

    I could have tell that I was negative even without the testing (yeah, a smart ass :)), because I felt improvement in overall health lately. More energy, better mood, a few pounds added etc. Still, very stressed-out waiting for the results…

    The plan is to check again by the end of this year, or earlier – in case of any doubt. This is the legacy from my previous treatment with PEG/RIB and it is going to take some time to get rid of this relapse paranoia.

    Thanks to all forum members (and dr. F of course) who share their experience and knowledge and keep this site going!

    For those who are having or are waiting for a second round of DAA’s – fingers crossed for you guys! You are almost there, just think positively!!

    G1a 2004.
    Peg/riba 2006, SVR 24.
    Control PCR in 2010 – around 4.000 IU/ml.

    Confirmed genotype 1a. Fibroscan F0-F1 (2011).
    PCR between 10 – 250 IU/ml (July 2016)

    Ledifos (SOF/LED) September 2016
    ALT/AST 20/21
    08th October – 4 weeks ALT24 AST18
    05th November – 8 weeks ALT17 AST16
    29th November – EOT 🙂 AST 20 ALT 41
    22 February 2017 – SVR 12!
    ALT 14, AST 14

    20 December 2016 at 9:58 pm in reply to: Day 1… here we go #24768
    1a2x
    • Topics: 1
    • Replies: 10
    • Total: 11
    • Acolyte
    • ★★
    @1a2x

    Congratulations on your first UND! Well done ;-)

    Please add details about your fibrosis level. It is an important piece of info for making a decision about the lenght of your treatment.

    G1a 2004.
    Peg/riba 2006, SVR 24.
    Control PCR in 2010 – around 4.000 IU/ml.

    Confirmed genotype 1a. Fibroscan F0-F1 (2011).
    PCR between 10 – 250 IU/ml (July 2016)

    Ledifos (SOF/LED) September 2016
    ALT/AST 20/21
    08th October – 4 weeks ALT24 AST18
    05th November – 8 weeks ALT17 AST16
    29th November – EOT 🙂 AST 20 ALT 41
    22 February 2017 – SVR 12!
    ALT 14, AST 14

    19 December 2016 at 3:57 am in reply to: Baseline VL below detection #24745
    1a2x
    • Topics: 1
    • Replies: 10
    • Total: 11
    • Acolyte
    • ★★
    @1a2x

    Finished my therapy with the end of November. The second half of it was worse than at the beginning, less energy most of all. Nothing unbearable, but I’m glad it is over :) now it is all about waiting. Yes, sleeping, healthy diet and a lot of water, and exercise will help.

    ALT at the EOT was a bit higher than usually, still in range, so no major worries at this point. I will re-test in a week or so anyway.

    No VL done at all, that’s the savings for 2016 ;-)

    question: are Fibroscan results and MELD score in line for less fibrotic patients and are they in line in general? Or, is MELD score relevant for general assessment of liver health? They both should be predictive but can MELD say 7 (which should be relatively good), and FS grade 4? I didn’t have a Fibroscan since 2011., so I am trying to fill in the gaps with blood results from the beginning of this year…

    G1a 2004.
    Peg/riba 2006, SVR 24.
    Control PCR in 2010 – around 4.000 IU/ml.

    Confirmed genotype 1a. Fibroscan F0-F1 (2011).
    PCR between 10 – 250 IU/ml (July 2016)

    Ledifos (SOF/LED) September 2016
    ALT/AST 20/21
    08th October – 4 weeks ALT24 AST18
    05th November – 8 weeks ALT17 AST16
    29th November – EOT 🙂 AST 20 ALT 41
    22 February 2017 – SVR 12!
    ALT 14, AST 14

    6 November 2016 at 2:18 pm in reply to: Baseline VL below detection #24195
    1a2x
    • Topics: 1
    • Replies: 10
    • Total: 11
    • Acolyte
    • ★★
    @1a2x

    Just a brief update:

    4weeks blood results are not as I expected it to be – lower ALT/AST compared with pre-treatment results. ALT was actually a bit higher. Nothing to worry about, but it would give me some more confidence, to be honest.

    8weeks – now this is what I expected to see. I’m aware that only VL counts; however, these results are the best I had in last 5 years (although they had been similar and all in range for that period anyway)

    Harvoni high had gone with the end of first month. Brain fog and great amount of tiredness are the only ‘major’ sides I feel and I have to say they are more severe than pre-treatment. With less than 4 weeks until the EOT, nothing to be worried about.

    My diet is not as strict as at the beginning of treatment. Increased apetite is an excuse ;-)

    Warm regards to all fellow patients and FHC team!

    G1a 2004.
    Peg/riba 2006, SVR 24.
    Control PCR in 2010 – around 4.000 IU/ml.

    Confirmed genotype 1a. Fibroscan F0-F1 (2011).
    PCR between 10 – 250 IU/ml (July 2016)

    Ledifos (SOF/LED) September 2016
    ALT/AST 20/21
    08th October – 4 weeks ALT24 AST18
    05th November – 8 weeks ALT17 AST16
    29th November – EOT 🙂 AST 20 ALT 41
    22 February 2017 – SVR 12!
    ALT 14, AST 14

    30 September 2016 at 10:26 pm in reply to: Baseline VL below detection #23374
    1a2x
    • Topics: 1
    • Replies: 10
    • Total: 11
    • Acolyte
    • ★★
    @1a2x

    PLT ~ 215. 170 and above during the last 3 years, the last result was the highest. Thank you for the hint.

    2x is for fighting it the second time (the final one hopefully). 1a before INF/RIB, 1a present day. Wanted to exclude the possibility of re-infection (in a way), although I was 99% sure it was a relapse. Maybe 6 months after the therapy was a fail test, maybe test was not sensitive enough those days? I can recognize few risks – dental works, blood test sampling, etc.? Other than that I can’t recall a situation where I was at risk, which does not mean there had not been any.

    Low VL is another thing that I am unsure about. Makes me think it was a relapse; then it does not make much sense, because most of people show significant numbers (over million), from what I have seen in other statistics here and there). Maybe it is not important, since low VL is not connected with fewer or milder symptoms, from what I had experienced.

    Regards

    G1a 2004.
    Peg/riba 2006, SVR 24.
    Control PCR in 2010 – around 4.000 IU/ml.

    Confirmed genotype 1a. Fibroscan F0-F1 (2011).
    PCR between 10 – 250 IU/ml (July 2016)

    Ledifos (SOF/LED) September 2016
    ALT/AST 20/21
    08th October – 4 weeks ALT24 AST18
    05th November – 8 weeks ALT17 AST16
    29th November – EOT 🙂 AST 20 ALT 41
    22 February 2017 – SVR 12!
    ALT 14, AST 14

    29 September 2016 at 2:18 am in reply to: Baseline VL below detection #23338
    1a2x
    • Topics: 1
    • Replies: 10
    • Total: 11
    • Acolyte
    • ★★
    @1a2x

    Hello everyone,

    an update, as I had found many useful info by reading other people posts (thank you all :)), so mine could be of help to someone..
    Started with generic Harvoni three weeks ago. Very mild sides, random neck, muscle or joint pain. If so…

    Beside that, feeling excellent most of the time. More chatty, energized, maybe even high at the moments… Hope it is going to last during the whole therapy :)

    More important, I hope that this drug will do what it was invented for. Although my LFT was good since INF/RIB therapy (never had higher AST/ALT in 10 years, checked at least annually; other results OK too, only slightly higher cholesterol), I didn’t feel good at all last couple of years. That’s what brought me here, two or three months ago when I felt more crappy than usually. I wanted to check if something has changed in HepC world and discovered this wonderful world of generic DAA’s.

    Anyway, because of my odd baseline scores (very low VL, normal blood results) and due to the fact that I could not reach my doctor to tell him about the therapy and ask for opinion, I’ve decided not to test VL during the treatment. It is going to be hard not to see the progress in written, I can only hope that ALT will show some good signals. Slim chances tho, steady 17-21 last couple of years.

    The only thing that bothers me is that Fibroscan is not up to date. Makes me a bit uncertain if 12 weeks is going to be sufficient.

    To whom it may concern:
    – taking the meds 1-2 h after the dinner. It makes me wanna eat, and eat, and eat some more…
    – strange feeling (numbness sort of) in my hands circa 10th day of therapy. After that, I started feeling hands like they are mine again. Somebody wrote similar in other post, I think
    – smoking, well I am vaping! E-cigs! I know it is not wise, but it seems I cant get rid of it…
    – reduced coffee to two cups per day, and one cup of green tea in late afternoon
    – avoiding carbohydrates as much as possible (sweets, pasta etc.) Eating better ones.
    – enough water, not drowning in it. around 2.5-3 l
    – Vit D, vit B
    – alco free, of course

    Take care, everyone :)

    G1a 2004.
    Peg/riba 2006, SVR 24.
    Control PCR in 2010 – around 4.000 IU/ml.

    Confirmed genotype 1a. Fibroscan F0-F1 (2011).
    PCR between 10 – 250 IU/ml (July 2016)

    Ledifos (SOF/LED) September 2016
    ALT/AST 20/21
    08th October – 4 weeks ALT24 AST18
    05th November – 8 weeks ALT17 AST16
    29th November – EOT 🙂 AST 20 ALT 41
    22 February 2017 – SVR 12!
    ALT 14, AST 14

    21 July 2016 at 1:35 am in reply to: Baseline VL below detection #21163
    1a2x
    • Topics: 1
    • Replies: 10
    • Total: 11
    • Acolyte
    • ★★
    @1a2x

    I had cancelled genotype determination (the lab cannot guarantee readable results with such low number of copies). Instead, qualitative test was done and it showed positive result. The limit is 10 IU/ml for qualitative.

    G1a 2004.
    Peg/riba 2006, SVR 24.
    Control PCR in 2010 – around 4.000 IU/ml.

    Confirmed genotype 1a. Fibroscan F0-F1 (2011).
    PCR between 10 – 250 IU/ml (July 2016)

    Ledifos (SOF/LED) September 2016
    ALT/AST 20/21
    08th October – 4 weeks ALT24 AST18
    05th November – 8 weeks ALT17 AST16
    29th November – EOT 🙂 AST 20 ALT 41
    22 February 2017 – SVR 12!
    ALT 14, AST 14

    11 July 2016 at 10:26 pm in reply to: Baseline VL below detection #20834
    1a2x
    • Topics: 1
    • Replies: 10
    • Total: 11
    • Acolyte
    • ★★
    @1a2x

    Hi Price,

    shouldn’t it say UNDETECTED in case it is ‘cleared’? Talking about quantitative PCR…

    In my case, negative qualitative PCR 6 months after the end of peginf/riba treatment. 4 years after that, quantity was between 3-4.000 IU/ml (detection limit is not stated in results!) and now, 10 years after the therapy it is <250.

    From what I read, quantitative results are stated either as undetected, upper limit.
    http://fixhepc.com/forum/viral-load-and-svr/364-viral-load-quantitative-vs-qualitative.html

    I just had a call from a doctor who performs these quantitative tests. She said that <250 means that they cannot say either positive or negative. There may be a small quantity of virus present, but it could be that it is not there. (excuse me, what am I paying for??) I will call her tomorrow when she is in the lab again, so she will take another look at my results. She says that some conclusions can be drawn from 'appearance of curves or whatever she looks at'. (that is my interpretation, I could not listen scientific rationales, I wanted a clear statement)
    She suggested to do qualitative test to be sure. I will, if she pays for it :)

    Now, my specialist says that result <250 means that the virus is still present. I trust this doctor and I feel that she is right. I feel it right below my right set of ribs...

    Anyway, I gave blood sample for genotype test today, expecting results in 7-10 days. Does anyone know, would testing of genotype result in (conclusive) determination of genotype, in case that the patient was previously treated and reached SVR52, for example?

    G1a 2004.
    Peg/riba 2006, SVR 24.
    Control PCR in 2010 – around 4.000 IU/ml.

    Confirmed genotype 1a. Fibroscan F0-F1 (2011).
    PCR between 10 – 250 IU/ml (July 2016)

    Ledifos (SOF/LED) September 2016
    ALT/AST 20/21
    08th October – 4 weeks ALT24 AST18
    05th November – 8 weeks ALT17 AST16
    29th November – EOT 🙂 AST 20 ALT 41
    22 February 2017 – SVR 12!
    ALT 14, AST 14

    10 July 2016 at 6:39 pm in reply to: Baseline VL below detection #20784
    1a2x
    • Topics: 1
    • Replies: 10
    • Total: 11
    • Acolyte
    • ★★
    @1a2x

    It is quite different here in Serbia and it surely is not better than in UK. I’ve sent a query to other laboratory to tell me the lower limit for their test.
    From what I’ve heard, that laboratory is subcontracted to the laboratory where I had my test done. However, the same test is almost double in price (app. 80 EUR Vs. 170 EUR) so I believe it could be more accurate. In that case, I will have to do another one.

    Unfortunately, it is very hard to reach my specialist (or any other for that matter). I have to wait the end of this month to call them and schedule a meeting for September, if I am lucky. Even after that, it is very unlikely that they can order PCR HCV – they do it only in case when somebody is on treatment (budgeted by NHS, lets call it that way).

    So, I decided to have all tests prepared (as if I am starting with Redemption), and I will decide which way to go.

    G1a 2004.
    Peg/riba 2006, SVR 24.
    Control PCR in 2010 – around 4.000 IU/ml.

    Confirmed genotype 1a. Fibroscan F0-F1 (2011).
    PCR between 10 – 250 IU/ml (July 2016)

    Ledifos (SOF/LED) September 2016
    ALT/AST 20/21
    08th October – 4 weeks ALT24 AST18
    05th November – 8 weeks ALT17 AST16
    29th November – EOT 🙂 AST 20 ALT 41
    22 February 2017 – SVR 12!
    ALT 14, AST 14

    10 July 2016 at 1:13 pm in reply to: Baseline VL below detection #20779
    1a2x
    • Topics: 1
    • Replies: 10
    • Total: 11
    • Acolyte
    • ★★
    @1a2x

    Hi LG, I will check whether there is more accurate test available – but I doubt its sensitivity will be close to 15 IU/ml limit, even if there are such tests here…
    I guess that idea behind your question is to see more accurately the drop of VL after 4 weeks, correct?

    In case that more sensitive tests are not available, is qualitative test the correct tool for tracking the VL during the therapy? It should tell us detected/undetected instead of giving us the exact values, right?

    These questions are probably for the specialist, but I wanted to hear opinions from people from here. I could not find similar case in other topics.

    G1a 2004.
    Peg/riba 2006, SVR 24.
    Control PCR in 2010 – around 4.000 IU/ml.

    Confirmed genotype 1a. Fibroscan F0-F1 (2011).
    PCR between 10 – 250 IU/ml (July 2016)

    Ledifos (SOF/LED) September 2016
    ALT/AST 20/21
    08th October – 4 weeks ALT24 AST18
    05th November – 8 weeks ALT17 AST16
    29th November – EOT 🙂 AST 20 ALT 41
    22 February 2017 – SVR 12!
    ALT 14, AST 14

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Viewing 10 posts - 1 through 10 (of 10 total)