Forum Replies Created
-
AuthorPosts
-
Thank you James,
I have been considering whether to continue Dac/Sof regimen with or without Riba as I am about to finish 12wks of Dac/Sof and with Geno 3a
and no fibrosis etc I am fairly confident to stay at 12 weeks based on that latest data.
Nobody knows yet what the long term potential side effects, if any, of those DAAs are, so absolute minimum is my belief.
The only weakness in those outcomes as far as I am concerned is the male/female ration of the different arms. I do not know if that is relevant but I dont think it has been clarified if it is NOT relevant.Berrinice, it is true and it is well documented that the iron in meat is much more readily accessible, but that does not mean that a plant based diet is inadequate for iron. It all depends on how much Vit B12 there is and also Vit C. That is also in the scientific literature. (by the way I am not a vegetarian for the last 20 years but was one for 15 years)
Actually Berrinice, I am not sure that is quite so. The biggest issue with absorption of iron or the bodies use or it is the availabitliy of Vit B12 in most vegetarians. Also many millions of people in India live as vegetarians and, outside of the effect of pure poverty, do not suffer from low iron.
And another insider story on this subject. I have a friend who lives in China and is married to a Chinese woman who is a Western medical doctor in the hospital system in a prominent position looking after retired political members.
Every weekend she is offered a holiday in a Chinese holiday destination 5-6 stars. She is also given kickbacks in her pay each time she writes a script for a particular drug and the hospital also receives kickbacks. No matter how you dress this up or what you call the payments they are kickbacks and incentives, and who is going to pull the plug on that? Deep levels of corruption in any other industry. Dont think that this only happens in China! Those companies are multi nationals and when you start to talk of 11 billion profit in 1 year from 1 drug, extrapolate that into a few more dozen drugs. A lot of buying power yes!I think you will find that that conversation is happening regularly around the world for most of the common drugs pushed in obscene quantities often on spurious/questionable research. The amount of articles and books now being written by PROMINENT players in the field of medical research is getting larger and larger. They all point to the same corruption and criminal greed within the present medical research and marketing of drugs in the world. ie ex editor and sub editor of the British Lancet Journal, one of the founding members of the Cochrane review etc. I have been reading and studying in this area for the last 30 years. It is only when a lot of people all of a sudden due to their own personal circumstances discover this unhealthy truth.
So UND at 24 weeks would be a much more logical end point in this research. I therefore reiterate that the above research has fudged or fuzzy outcome numbers.
Hi Zhuk thanks for that.
The point I am trying to make is that the end point in the study was to have HCV RNA detected by less than 15… So that is not a cure is it? The following is lifted straight from the NEJM article where it appeard:Study End Points
The primary efficacy end point was the rate of sustained virologic response (defined as HCV RNA <15 IU per milliliter) at 12 weeks after the end of treatment in all patients who underwent randomization and received at least one dose of a study drug. Secondary efficacy end points included the change from baseline in the CPT and MELD scores at 12 weeks after the end of treatment.They then go on to state all these percentages of cure when the above Study End pt does not say that. It says still detected but under countable limits.
Is this skewed research or am I missing something?What I found interesting with these studies is that the end point or SVR12 was defined as :
In that study, 99% of patients were cured, where a cure was defined (as in all the studies) as a serum HCV RNA level of less than 15 IU per ml measured 12 weeks after the end of therapy — the so-called SVR12.
http://www.medpagetoday.com/MeetingCoverage/AASLD/54749?xid=nl_mpt_DHE_2015-11-18&eun=g696864d0r
So not zero detection but less than 15IU per ml.
Have I misunderstood as my understanding is it shouldnt have any detection as SVR12 or 24:
“The changing role of SVR12 in clinical trials of HCV drugs
So is the above inconsistent with this?“In clinical trials of therapy for hepatitis C virus (HCV) infection, the standard to assess the effectiveness of treatment has been the decline of HCV RNA (viral load) during therapy such that it becomes very low followed by undetectable viral load for 24 consecutive weeks after therapy has ended. Such a response in the 24 weeks after the cessation of therapy is called a sustained virologic response, written as SVR24.”
All of those symptoms sound like the ‘usual’ viral symptoms one gets with a flu. I also believe they are like a poisoning in the body. Whether it is the virus or the drug who knows but something major is going on.
On day 7 or so of my Sof/Dac treatment I developed severe joint pain and could barely walk or even sit up. That all passed after about 4 days, and since that time just one knee has remained active (on week 9 now) I have had no joint pain in my body to speak of up till then.
Fantastic news Sir!! Looking forward to hearing how it goes for you. Good luck
Thank you so much every body for those great cheers from the sides!! I am sure that nearly of us will have this same outcome and look forward to hearing the great news from everyone else.
Poodle I think that I do not have fibrosis because I have lived like a Yogi really for most of that time. Mostly very healthy diet and exercize PLUS no alcohol since my early twenties up until a few years ago. I think that is when some of my overt symptoms started but still no fibrosis considering I am a Geno 3a which is supposed to have a higher incidents of serious side effects. I would really like to hear from others about their alcohol use over their lives and see if that may be a co factor in the development of cirrhosis/fibrosis. My understanding is that is a suspected link.
Hi Rowan,
happy you found this great bunch. What genotype are you? It is amazing how quickly we are all clearing the virus with minimal side effects, certainly compared to the other toxic substances used. Good luckI was developing severe tinnitus and a head full of cottonwool and fog with some increasing dizziness and general ‘weirdness’ in the head for the month or 2 before I started dac/sof treatment about 6 weeks ago. The fogginess etc cleared I think within the first week or 2, and only just realized that tinnitus has subsided to about a 2/10 as opposed to about a 7/10. Woo hoo. The other way to think about it increasing is that it might have been aside effect of die off of either the virus or the liver cells themselves. Often when treating a virus/bacteria there is a toxic load increase in the blood or maybe the liver which is cleaning the blood of debris. Might explain why some increase in toxicity/damage could be causing an increase in tinnitus in susceptible patients. Whereas I believe my toxic viral load or liver damge was increasing prior to treatment and was quickly brought down by treatment as evidenced by the dramatic improvement in liver function.
Oh also no Fibrosis at all detected etc. I was having Liver function going up for the last 1 1/2 years and starting to feel very crazy and unwell with memory and energy and emotions and digestive symptoms. Nearly all of those cleared quite quickly on the meds.
Thank you Nadia. I think the options are extending the time I am on the Sof/Dac +/or adding Riba to the mix. I am very reluctant to go down that Riba road. There is some interestin pan geno drugs in research still. Anyway will just see also what James recommends.
-
AuthorPosts
