I came across a couple forum discussions suggesting that increasing the duration of treatment from 12 weeks to 16 or 24 may be beneficial for GT3 patients without cirrhosis. I’m on my last bottles of Dac/Sof (week 10). My data is the following:

GT3a, treatment experienced (interferon + riba), fibroscan – 7.5 (F2),

Pre-treatment (September 2015):
HCV RNA QUANTITATIVE: 2,487,537 IU/mL
ALT(SGPT): 64 U/L (1-53 U/L)
AST (SGOT): 32 U/L (1-50 U/L)
GAMMA GT: 47 U/L (10-54 U/L)

Week 3.5 during treatment (Jan 2016):
HCV RNA QUANTITATIVE: <15 IU/mL
ALT(SGPT): 31 U/L (1-53 U/L)
AST (SGOT): 18 U/L (1-50 U/L)
GAMMA GT: 27 U/L (10-54 U/L)

My doctor is taking it easy, so the next time she wants to see me is one month after the completion of my treatment. She said that there is no point of tests during the treatment other than the week 4 test.

My question is does it make sense to extent my treatment? If so what would be the recommended duration?

I purchased the meds from Mesochem and encapsulated them, back in October last year. However after several appeals the insurance company ended up approving the medication and I have been on the original Dac/Sof. However, I still have the 3 months’ supply from Mesochem in my fridge, so I can’t start taking them if it will increase my chance of getting cured.

Thank you in advance for the reply.

Cheers,
Cole

Hey zhuk,
My insurance company is denying the dac + sof treatment, they are indicating that they may approve sof+interferon+riba, (most likely they will make me go again through 3 appeals). I’m genotype 3, they are following the AASLD guidelines – the triple regime is one of the two recommend regimes for my genotype. However, my previous treatment with interferon+riba was really hard and my doctor is refusing to make me go through it again. Further, she said that she hasn’t treated a patient with inter+riba in more than 2 years and she doesn’t see the point of doing it. According to her student and union insurances, as well as Medicare are almost impossible to get approval for treatment (I’m on a student insurance). Anyways, we are at the final stage of the appeal process, lets see what will happen. I really want to win it, mainly because Aetna has been assholes and I don’t mind setting them back with a couple grants. Earlier this year they denied sof+riba for 6 months (not sick enough, so no medical necessity), back then we didn’t bother appealing, since we knew that daclatasvir will be approve during the summer so we decided to wait. Anyways, i have the meds from mesochem will start them in two weeks, once i hear from the Department of Health about the appeal.

The detailed information from you helped me make the decision. Thanks again!

I was thinking of doing 2 separate capsules – 400 mg Sofosbuvir and 60mg Daclatasvir. I will talk to Torpac tomorrow, they may have not shipped it since i ordered it on Thursday evening from them. You are right they are about 1h drive from home i can always switch it. Just wanted to check before i open the package. Thanks again.

Hey,

I ordered the torpac size 0. Can i fit 400mg sofosbuvir in size 0 capsules?

thanks.