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  • 28 January 2017 at 6:06 am in reply to: Are New Drugs for Hepatitis C Safe? A Report Raises Concerns #25154
    DrD
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    @drd

    Gaj-
    Yes, I agree;
    “As such the level of testing before and after treatment should be appropriate to the risk factors for the individual patient and I would be surprised if monitoring doctors did not include CBC, LFT, etc during treatment.”
    However, I think you and I both know there are MANY PEOPLE who will obtain these meds without the benefit of having monitoring docs. This is the real world and many people out there cant even afford a primary care doc. When those very people begin tx because they have enough $ to get meds from India, Bangladesh, etc….I believe they should have all the info available- including potential adverse events no matter how small the risk.
    Thank you for your replies- both informative and thoughtful.

    28 January 2017 at 12:51 am in reply to: Are New Drugs for Hepatitis C Safe? A Report Raises Concerns #25150
    DrD
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    @drd

    Is anyone talking about this?

    https://www.nytimes.com/2017/01/24/health/hepatitis-c-antiviral-drug-study.html?_r=0

    As the authors of the review note (please see attached PDF) there are many unanswered questions, however, liver failure and reactivation of Hep B (in those previously afflicted) are not minor issues. Although the review does not address the new pangenotypic daa’s (Beacon’s Sofosvel, Incepta’s Panovir, etc…;) the data is clearly referencing the sofosbuvir backbone meds.
    In light of recognizing these issues it would seem that simple before and after lab tests (pre and post 12 or 24 week tx) might not be sufficient. For patients moving forward with treatment it might be wise to add several points of lab testing (cbc, hep b panel, iron studies, liver fxn tests, etc..) DURING treatment course. This might allow any potential adverse effects to be caught before they are fully manifested.

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