Here is the Phase 3 for UNITY-2

http://www.natap.org/2014/AASLD/AASLD_23.htm

So the results are ok but Daclatasvir+Asunaprevir+Beclabuvir appears to need RIBA to get to the results delivered by other combinations.

Summary

Coadministration with ledipasvir/sofosbuvir has not been studied and is not recommended. Coadministration of simeprevir (150 mg once daily) and ledipasvir alone (30 mg once daily) to 22 subjects increased ledipasvir Cmax and AUC by 81% and 92%. Simeprevir Cmax and AUC increased by 161% and 169%. Coadministration of simeprevir (150 mg once daily) and sofosbuvir alone (400 mg once daily) increased sofosbuvir AUC and Cmax by 3.16- and 1.91-fold, respectively when compared to historical data. The AUC of GS-331007 (the main metabolite) increased by 9%, but Cmax decreased by 31%. Simeprevir AUC and Cmax decreased by 6% and 4%, respectively.

Description

Concentrations of ledipasvir, sofosbuvir and simeprevir are increased when simeprevir is co-administered with ledipasvir/sofosbuvir. Co-administration is not recommended. Coadministration of simeprevir (150 mg once daily) and ledipasvir (30 mg once daily) increased simeprevir Cmax and AUC by 161% and 169%; ledipasvir Cmax and AUC increased by 81% and 92%. Coadministration of simeprevir and sofosbuvir decreased simeprevir Cmax and AUC by 4% and 6%, increased sofosbuvir Cmax and AUC by 91% and 216%, and decreased GS-331007 Cmax by 31% but increased AUC by 9%.
Harvoni Summary of Product Characteristics, Gilead Sciences Ltd, November 2014.

Concentrations of ledipasvir and simeprevir are increased when simeprevir is coadministered with ledipasvir. Coadministration of simeprevir (150 mg once daily) and ledipasvir (30 mg once daily) to 22 subjects increased ledipasvir Cmax and AUC by 81% and 92%. Simeprevir Cmax and AUC increased by 161% and 169%. Coadministration of ledipasvir/sofosbuvir with simeprevir is not recommended.
Harvoni US Prescribing Information, Gilead Sciences, October 2014.

I’ve lost my youthful years, but to feel well, before I become old, will be a reprieve.

We are all the product of all the people we have ever met, and the things we’ve done and have between now and whenever our time runs out to do whatever it is…

My mum once told me something useful:

“Life is not a trial run.”

Get cured and find your new future, whatever it might be.

Hi Tina, how about a Pacific fusion tune

[video]https://www.youtube.com/watch?v=9Nbxryb5YHc[/video]

So these 3 left a real impression the first time I heard them

[video]https://www.youtube.com/watch?v=Y2Ta0qCG8No/[/video]

[video]https://www.youtube.com/watch?v=gxEPV4kolz0[/video]

[video]https://www.youtube.com/watch?v=h0ffIJ7ZO4U[/video]

Hi Tomas,

For somebody with HCV it really does not get better than that prior to treatment.

With low fibrosis you chances of cure are at the higher end. No 100% cast iron guarantee but good reason to be optimistic.

Thank you Paul.

Here are a few facts:

1. In India these medications are listed on Schedule H which is, like Australia’s Schedule 4 ie prescription only https://en.wikipedia.org/wiki/Drugs_and_Cosmetics_Rules,_1945
2. The fact that it is possible to get these medications in India without a prescription does not make that legal – I can for example get MS Contin on the street in Australia without a prescription and that is not legal either
3. As a rule, if laws are being bent or broken it’s not a very sensible idea to make a fuss about that on a public forum

India also has a Schedule X, similar to Australia’s S8 in terms of lock and key storage, and extensive record keeping. Consider that in 2014 India rescheduled Ketamine onto Schedule X http://timesofindia.indiatimes.com/city/goa/Ketamine-drug-brought-under-Schedule-X-to-curb-abuse/articleshow/28486002.cms and then consider if there might be very influential and cashed up organisations who might be lobbying for exactly that outcome to ensure compliance with licensing arrangements.

It is fantastic that these medications can be accessed.

Please don’t kid yourself that both accessing them and having them in your possession almost anywhere in the world is legal without a prescription. It is almost certainly not.

The mortality rate on some of the trials has been > 1:100 (Velpatasvir was 1:177) so don’t kid yourself that these medications are completely safe and that you should just take them without having had a chat with a doctor to get your prescription.

While I am inherently opposed to censorship please consider that websites that provide information on how to conduct illegal activity have historically been shut down.

Please be prudent in your comments and consider that not everyone who reads them is a fan of our mission to see everyone, everywhere provided with timely and affordable access to DAA medication.

To anybody who may be willing or able to provide medications without a prescription I would urge you to consider the wisdom of a) doing so and b) telling the world. Your next customer may be from the FDA/DEA or equivalent, so to be blunt get a clue and make sure your behaviour is compliant with all local laws.

Sometimes saying less is more. Please don’t paint a target on yourself or this website.