Forum Replies Created
-
AuthorPosts
-
Tina has incited me to post a few tunes, so here are 2
[video]https://www.youtube.com/watch?v=iQI5fdVCvlU[/video]
[video]https://www.youtube.com/watch?v=Tu7HoGZaspo[/video]
YMMV
Hey Mike I will be finished in exactly three weeks so not far behind you…….
YMMV
If you’re Geno 1a Sof +Led has the best cure rate with Sof + Dac more of a generalised treatment irrespective of reflux problems
Sof+Dac
GT1 ALLY-2 naive (80/83) experienced (43/44) Aggregate 96.8% (123/127)
GT1a ALLY-2 naive 96% (68/71) experienced 97% (32/33) Aggregate 96.2% (100/104)
GT1b ALLY-2 ALLY-2 naive 100% (12/12) experienced 100% (11/11) Aggregate 100% (23/23)
Past Failure ALLY-2 98% (43/44)Sof+Led
GT1 ION-1 98% (142/145) ION-3 96% 96% (165/172) Aggregate 96.8% (307/317)
GT1a ION-1 98% (142/145) ION-3 96% 96% (165/172) Aggregate 96.8% (307/317)
GT1b ION-1 100% (67/67) ION-3 98% (43/44) Aggregate 99.1% (110/111)
Past Failure ION-3 94% (102/109)Not a lot between them, but the data for Sof+Led is more robust due to better n
With F4
Sof+Dac ALLY-2 naive 89% (8/9) experienced 92% (12/13) Aggregate 91% (20/22)
Sof+Led ION-1 97% (32/33)So although Sof+Led looks better on % basis the entire stats for Sof+Dac and Sof+Led are based on 55 patients, of whom 3 failed.
PPIs prevent Ledipasvir absorption so I would recommend Sof+Dac
YMMV
B12 is water soluble so excess passes out in your urine. You need about 2.5 IU a day and there is often 5-10 IU in mixed B and multivitamin preparations. “Pure” B12 tablets often have 500-1000 IU.
Here is what the Mayo clinic has to say about B12:
http://www.mayoclinic.org/drugs-supplements/vitamin-b12/dosing/hrb-20060243
The bit about people taking high doses for years is reassuring.
10 IU as a minimum and 1000 IU as a maximum is a pretty wide range but somewhere in that range would be what I might take if faced with making a choice based on inadequate data.
YMMV
For people reading this INR 67,000 is $1000 USD ($996.40 to be exact) and Parag Jain is known to be honest.
This is the best street price in India.
If you see someone in India offering medication online below this price, and also including shipping (worth $80-100 USD via Fedex), you should read this:
IF IT SEEMS TOO GOOD TO BE TRUE, IT ALMOST CERTAINLY IS.
Please read what Greg Jefferys has to say about this:
http://blogs.hepmag.com/gregjefferys/2016/01/hepatitis_c_treatmen_21.html
Anything (Harvoni generic) out of India for much less than $1200 USD should be viewed with skepticism.
Anything below $1000 USD is unrealistic and likely to end in tears.
YMMV
Hello Frankiej
Good luck with your journey, which I’m sure will be a good one
YMMV
Good luck Honker. I lived is Tassie for two years way back when and it is a beautiful place to visit. Especially Coles Bay, picture perfect
YMMV
I think I put this post in the wrong place
Not anymore!
YMMV
Hello MtGoat,
You can see any GP online at https://gp2u.com.au/ and get a script that you can use at Kingswood.
YMMV
I had a call from the Nurse at the Liver Clinic at the Bendigo Base Hospital tonight. I met her when she came to my work place to give us all our flu shots last year. I had only just been diagnosed at that point and we got chatting and she said that she would probably be looking after me at the Clinic…well 10 months and counting and I am still waiting (will have to cancel at some point I guess). Anyway I told her my story and she said that she had had quite a few queries regarding the Buyers Club and now that she has actually spoken to someone who has taken that road she will be able to tell people that do query about it that she has spoken to someone who has taken the generic option and the positive outcome so far. She was very excited to hear of my progress and asked lots of questions regarding blood tests results etc. I was happy to give her all my positive news. Clearly the message is getting out there, even here in good old Bendigo!
The impression I got from her was that the medicos are not prepared to take the risk by writing scripts for generics. She did however say that she wondered how many people would be able to be treated when the meds are listed on the PBS here in March i.e. it was probably only going to treat those whose livers are really compromised……which is a fair enough comment I thought.
YMMV
Devil,
When there was a suggestion put on the forum – by you – that Harvoni would become available in NZ from Feb at the cost of “about $125 per week”
One of our members – zhuk – wrote to the NZ Ministry of Health, who int turn directed the query onto PHARMAC.
Below is a copy of PHARMACs response. Please read it, because it definitely does not say subsidised Harvoni will be available for “about $125 per week” as you have suggested. If your doctor told you this he appears to be wrong.
On a separate note we encourage open discourse, and referenced sources on this forum.
We do not tolerate offensive rants. This is your one and only warning about this. If any further unpleasant commentary is directed at any of our members your account will be closed. An apology would be good.
Here is the PHARMAC response about this question (the most relevant part is in bold):
Dear XXXX
Thank you for your email about funding for ledipasvir with sofosbuvir (Harvoni).
PHARMAC received a funding application for ledipasvir with sofosbuvir (Harvoni) in February 2015. The first step in assessing the funding of a new medicine is for the application to be reviewed by the Pharmacology and Therapeutics Advisory Committee (PTAC), our clinical advisory committee. PTAC also has multiple Subcommittees, including one that provides specialist advice on Anti-Infective treatments. These committees provide us with expert, objective advice on medicine funding opportunities.
Harvoni was discussed by PTAC at their meeting in May. The minutes from this meeting can be found here: http://www.pharmac.health.nz/assets/ptac-minutes-2015-05.pdf
It is important to note that PTAC does not make funding decisions. PTAC provides clinical advice to PHARMAC. Additionally, a positive recommendation from PTAC and/or its Subcommittee does not guarantee the medicine will be funded. It is just the first step in the process. PHARMAC must then assess a number of other factors. This will include economic and commercial considerations as well as the clinical advice we received from PTAC and the Subcommittee. Further details on the process that PHARMAC uses to make funding decisions can be found on our website here: http://www.pharmac.health.nz/assets/factsheet-0…unding-decisions.pdf.
You can follow the progress of this funding application using our online Application Tracker:
http://www.pharmac.govt.nz/patients/ApplicationTracker?ProposalId=1344
http://www.pharmac.govt.nz/patients/ApplicationTracker?ProposalId=1340
You will see on the Application Tracker, that these funding applications have been ‘ranked’. This means they have been ranked against all other funding applications currently under consideration. We regularly reassess the relative ranking of medicine funding applications which means the ranking can change over time.
Unfortunately, we are unable to provide a definitive timeframe for if or when a funding decision will be made for these medicines. This is because there are a number of factors that can affect the relative ranking and funding timeframe for a medicine. These include the success of commercial negotiations with the supplier (including changes in price of the medication), new clinical data and/or the other funding applications being considered at the same time. Further information on how PHARMAC works can be found on our website here: http://www.pharmac.health.nz/about/your-guide-to-pharmac/
We are unable to advise how much Harvoni would cost to purchase privately as it may vary between pharmacies. We recommend comparing prices between several pharmacies if possible.
I hope this information is helpful. Please feel free to contact us again if you have any further questions.
Kind regards
Lauren Grierson
PHARMAC
YMMV
Good luck to you Ariel…..beautiful words
YMMV
I have been taking Nexium with the Harvoni
Don’t do that.
Ledipasvir needs stomach acid for absorption and you will compromise treatment success with it by taking Nexium
Depending on what else you take you might be better off stopping the Ledipasvir, and changing it to Daclatasvir which does not have this issue.
YMMV
Hi Stew-H
I am onto my 9th week of Sof/Led. Only side effect was insomnia which has eased over time. I vaguely remember reading somewhere on the Forum or on the list of medicines that may interact that you shouldn’t be take meds for indigestion/reflux too close to the time you take your Sof/Led. I am no expert of course so hopefully someone else can confirm this for you one way or another. I take Pariet for heartburn/indigestion and take it in the morning and my Sof/Led at night around 8.30pm.
Good luck with your treatment. You will find a lot of support on this Forum.
Cheers Lynne
YMMV
-
AuthorPosts