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Viewing 15 posts - 1,666 through 1,680 (of 1,968 total)
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  • in reply to: Incase of Harvoni relapse whats next ? #6894
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    24 weeks treatment with Harvoni

    24 weeks treatment with Sofosbuvir + Daclatasvir

    12-24 weeks treatment with Sof/Dac or Sof/Led plus Simeprevir

    Abbvie Viekira Pak

    So longer, stronger or different.


    YMMV

    in reply to: velpatasvir or daclatasvir (pangenotypic) #6893
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    http://www.gilead.com/news/press-releases/2015/9/gilead-announces-svr12-rates-from-four-phase-3-studies-evaluating-a-oncedaily-fixeddose-combination-of-sofosbuvir-sof-and-velpatasvir-vel-gs5816-for-the-treatment-of-all-six-hepatitis-c-genotypes

    Treatment emergent serious adverse events occurred in 18 percent of patients and nine patients died.

    If you remove the placebo patients the n was 1593 so the death rate was 1 in 177.


    YMMV

    in reply to: Lynne’s Results #6890
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Just a quick bit of advice if I may ask……when I have finished my treatment in 7 weeks do I have another VL test then or do I wait for 3 months after I have finished? I think that wait will be more stressful than the last four weeks of waiting

    The PROTON trial of 200 vs 400 of Sofosbbuvir showed that on the 400 mg dose 100% of people who went undetected on treatment stayed UND at EOT (End of treatment) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968818/table/table1-1756283X13515825/ For the 200 mg dose only 94% hit UND at EOT but the SVR of 90% was almost the same as the 91% for the 400 mg dose.

    So in English if you’ve hit UND on treatment you will be UND at EOT so doing a test then is academic. Nice to see, but basically useless.

    At 4 weeks post treatment UND means a 96% chance of absolute cure, and at 12 weeks UND means 99%.


    YMMV

    in reply to: Lynne’s Results #6862
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello everyone

    The Doctor just gave me my blood test results and has asked me to see if the following may have something to do with the medication.

    Neutrophils 1.9
    Platelets 148

    Apparently these are just a little bit lower than normal and nothing to worry about but as I have never had results like this before he just wanted me to check. Will follow up again in one month. Liver function test was perfect!

    Thanks in advance.


    YMMV

    in reply to: Australian PBS listing in March! #6807
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I don’t think that EVERYONE will get the treatment…it will be those who are very unwell (as it should be) but will be triaged for sure. I can’t imagine that anyone diagnosed with Hep C, no matter how advanced (or not advanced), would want to put off treatment. I don’t for a moment regret accessing my meds and am well on the way to a cure. If I were to wait for the Hospital system to get treatment I suspect it would be a long wait. I am still on the waiting list for an appointment (which could be 18 months away). I think there will be many more people going down the generics road because $1 billion over five years won’t go that far really. :(

    Maybe I am a bit cynical but I have no trust nor faith in our Government or our politicians, on any level.


    YMMV

    in reply to: Hepatitis Australia #6690
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Just saw my story on the “Speak Out” forum with Hep Australia which I posted on 8/12. Glad they approved and posted it……..I made it short and sweet but to the point. It’s great to see that word is “getting out there”. It was the first site I visited when I found out I had the virus. :)


    YMMV

    in reply to: Hepatitis Australia #6669
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc
    in reply to: Kingswood Compounding Pharmacy … Sof, Dac, Led #6667
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Kingswood were using Gelatin caps that had this problem. Now they are using vegie caps that don’t. Problem solvered.


    YMMV

    in reply to: London Girl’s NHS Experiences #6659
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Well done Folho, good on ya,
    LG so glad you are getting closer to treatment. has been a cake walk for me so far. Just so happy to be getting better and giving my body a chance to heal. Day 25 on APIs, Hope you have an easy time of it also.


    YMMV

    in reply to: Lynne’s Results #6609
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Thank you all for your posts…..this Forum has kept me “sane” through the last five weeks and I confess I have a bit of a laugh at some of the posts. Laughter is good for the soul apparently. I am off to see my GP on Monday with a nice bottle of Red to give to him for Xmas. He has been a great support to me and no doubt will be on board with his other Hep C patients now.

    Just a quick bit of advice if I may ask……when I have finished my treatment in 7 weeks do I have another VL test then or do I wait for 3 months after I have finished? I think that wait will be more stressful than the last four weeks of waiting :cheer:

    I still have insomnia and a few headaches but nothing I can’t cope with and my energy levels are much better too. I also feel a sense of “calm” which I haven’t had for a very long time.

    I wish you all a very Merry Xmas and a happy healthy 2016.

    My heartfelt thanks go to Dr Freeman :)


    YMMV

    in reply to: Genotype 3’s info, updates corner #6539
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    http://fixhepc.com/forum/gt3/369-gt3-high-svr-rates-with-daclatasvir.html

    If you look at this post and the pdf you can see that for n=468 F3/F4 patients on Sof/Dac +/- Riba that for everyone who did 24 weeks the – Riba groups out performed the + Riba groups.

    Based on this being the biggest trial and best evidence to date I would be going…..

    Drugs (ribavirin), just say no.


    YMMV

    in reply to: Charitable Donations #6516
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi All,

    tasCAHRD have created a new dedicated location for HCV donations:

    https://www.givenow.com.au/fixhepc

    This will ensure that these donations are directed towards HCV only.


    YMMV

    in reply to: Herbs and liver safety #6250
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    And quite surprised too that science seems to have managed to come up with something really useful for a change.

    But where’s my hoverboard?

    [video]https://www.youtube.com/watch?v=eOH15_pqWZ4[/video]


    YMMV

    in reply to: Sof+Dac combined tablet RVR #6233
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Yes, but probably go 24 weeks or add Simeprevir or Riba


    YMMV

    in reply to: Jaz’s Sof/Dac Journey Gen 3a #6134
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Jaz I start my fifth week of treatment this week. Only side effect I have had is insomnia. Was very tired throughout the day for the first week (I take my capsules around 8.00pm) but have now noticed, even though I am waking early, that my energy levels throughout the days have improved greatly. I work full time and have had no problems at work (other than yawning a lot for the first week) :) Good luck with your treatment. I have found this forum to be wonderful and pretty much any question/doubts you may have can be answered here.

    Cheers Lynne


    YMMV

Viewing 15 posts - 1,666 through 1,680 (of 1,968 total)