Yes benzos can can used. The FAQs have a list of common medications you might want to use to save looking up the interactions:

http://fixhepc.com/kunena-2015-11-10/faq.html

Insomnia is a known side effect of these medications. Here is my generic advice about insomnia:

http://gp2u.blogspot.com.au/2015/02/how-do-i-fix-my-insomnia.html

Good morning everyone Does anyone have any hints as to what is okay to take for headaches while taking the medication. I have had a horrid headache since Wednesday and just can’t shake it. Other than that I am dealing okay with the insomnia (which I still have) and energy through the day not too bad at all Hope you are all travelling well.

Lynne

The FixHepC vision is simple. Treat everyone, everwhere, with no man woman or child left behind.

5040 tons of Sofosbuvir to make 12,600,000,000 tablets to treat 150,000,000 people

That is a mere 100 trucks like this full of API:

It’s easier to ask forgiveness than it is to get permission

– Rear Admiral Grace Murray Hopper

https://en.wikiquote.org/wiki/Grace_Hopper

This lady looks like she knows what she is talking about…..

Hi Gary,

Just do this:

There is nothing wrong with stepping back -2 hours a day like 2000, 1800, 1600, 1400, 1200, 1000, 0800 but it’s really not required – these medications are not like the mini pill where you really do need to take it within 3 hours of the same time every day. You have 20 hours of wiggle room and you are only using 6 if you go evening -> lunch -> morning

All your numbers are tracking OK and in line with reasonable expectations. I’m guessing GT3 ?

Hello Serg,

I will just go out on a limb and say you should not worry – first read the bit of the FAQs about how to store the medications:

http://fixhepc.com/kunena-2015-11-10/faq.html

If you think about the science of molecular stability at absolute zero a molecule is stable almost indefinitely because there is no atomic motion and thus no capacity to break down.

Heat can destroy a molecule, cold more of less can not destroy small organic molecules, although large organic molecules like for example egg white can be cooked (denatured) by putting them it into liquid nitrogen. Proteins are on a totally different scale to sofosbuvir, ledipasvir and daclatasvir which exist in a crystalline structure like sugar or salt (neither of which are destroyed by cold). Proteins are denatured because the temperature in which they “expect” to exist determines very complex conformations.

The breakdown of organic matter due to freezing (say with frostbite) relates to large ice crystals rupturing cell membranes. Snap freezing things like embryos and foods works because the ice crystals formed are so small they do not rupture the cell membranes.

Vitamins and co factors are of similar scale to the DAAs and we know that freezing preserves them, where as cooking with heat can damage them.

So in other words severe cold can damage very large complex things, but is unlikely to damage small organic molecules like DAAs.

Note that ledipasvir is by far the most unstable of the 3 common DAAs – it falls apart in chloroform for example.

Take the medication daily at roughly the same time each day, with or without food.

To change from morning to evening go morning, lunch, evening

To change from evening to morning go evening, lunch morning.

If you forget to take and it is < 20 hours late, take the dose. If you forget and it is 20-24 hours late, skip the missing dose and just have the next dose at the usual time.