Hello Splitdog,

It will definitely be after the FDA approval, but how fast depends on things that have not happened yet. They were pretty quick last time, but lots of things have to happen internally before they can release it.

Did you take Sofosbuvir + Velpatasvir or was it something else?

Hello Splitdog,

It’s not scheduled for approval until August 8 2017

The side effects of headache and insomnia happen in about 1 in 5 patients and come from Sofosbuvir which is in almost all the standard treatments.

Hello Wanod,

Sofosvel was the first generic on the market, and comes from Beacon in Bangladesh. They produce Darvoni and other DAAs.

Panovir was the second generic on the market, and comes from Incepta in Bangladesh. They produce Twinvir and other DAAs.

Velpanat was the first licensed Indian generic to hit the market, not in India, but in Nepal. It is made by Natco who tend to be the first to release medications, and do it via Nepal.

Now all the Indian manufacturers are supplying SOF+VEL combination tablets.

Undetected at 4 weeks is usually a good sign. Not 100% certain, but you reduced the chances of failure by 50% when you came up undetected.

Hi Kitty,

In terms of the drugs, they are now for all intents and purposes completely gone from your system.

In terms of long term after effects, many of the bits in your body from 2 months ago have now been replaced by new ones, and that process continues so some people who remain less than well post treatment certainly do improve over time, maybe because our bodies are avid recyclers. Maybe because time is a great healer.

Now that said I would be looking for other causes.

You know you have thyroid issues and being hypothyroid (or hyperthyroid) certainly wreaks havoc.

I’m not a great believer in most supplements but Vitamin D and Vitamin B12 seem to help some people who feel fatigued during treatment. This would be easy and cheap to try.

Routine health matters like get some sunlight, drink some water, eat a varied diet, get some exercise, get enough sleep, not too much booze, and smoking is bad, are all basic mothercraft advice but worth looking at.

Having had Hep C places you at higher risk of all sorts of diseases. Getting older, and we all are, also means lots of other things can happen.

Diabetes is very common. Various cancers – blood, lymph and kidney all happen more commonly as well as the well known liver cancer risk.

So it might actually be worth going to another doctor and not mentioning you’ve either had Hep C or been treated. At least at the first consultation. Without that knowledge, they will be forced to look at you with fresh eyes, and no distortions due to pre-conceived notions.

If I was meeting you for the first time we’d start with the story of what’s happening, we have a look at you physically and I’d order a fishing net set of blood tests something like:

CBC, CMP (LTFs and UECs), Thyroid, Blood Sugar, Iron, B12, Folate, Vit D, Ca/Mg/PO4, CRP, ESR

Usually something turns up to give us a hint.

Hi Keith,

You should go well. The success rates for 8 weeks Harvoni are simply not as good at 12, regardless of meeting the criteria.

12 weeks Harvoni from the NHS in the first place would have probably done the trick, but at that stage (probably still now) people are still trying to save dollars with this.

Best of luck with it. I’d be backing you for the win.

Hello Heatherlou30,

Yes, while taking Daclatasvir you should not take anything with TAURINE in it which includes most of the common energy drinks, but not Coke and Pepsi which only have caffeine.

This is important because it may reduce the levels of daclatasvir and lead to treatment failure.