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“Word Perfect Technical support; may I help you?”
“Yes, well, I’m having trouble with WordPerfect.”
“What sort of trouble?”
“Well, I was just typing along, and all of a sudden the words went away.”
“Went away?”
“They disappeared.”
“Hmm. So what does your screen look like now?”
“Nothing.”
“Nothing?”
“It’s blank; it won’t accept anything when I type.”
“Are you still in WordPerfect, or did you get out?”
“How do I tell?”
“Can you see the C: prompt on the screen?”
“What’s a sea-prompt?”
“Never mind. Can you move the cursor around on the screen?”
“There isn’t any cursor: I told you, it won’t accept anything I type.”
“Does your monitor have a power indicator?”
“What’s a monitor?”
“It’s the thing with the screen on it that looks like a TV. Does it have a little light that tells you when it’s on?”
“I don’t know.”
“Well, then look on the back of the monitor and find where the power cord goes into it. Can you see that?”
…..”Yes, I think so.”
“Great! Follow the cord to the plug, and tell me if it’s plugged into the wall.”
…..”Yes, it is.”
“When you were behind the monitor, did you notice that there were two cables plugged into the back of it, not just one?”
“No.”
“Well, there are. I need you to look back there again and find the other cable.”
…..”Okay, here it is.”
“Follow it for me, and tell me if it’s plugged securely into the back of your computer.”
“I can’t reach it.”
“Uh huh. Well, can you see if it is?”
“No.”
“Even if you maybe put your knee on something and lean way over?”
“Oh, it’s not because I don’t have the right angle-it’s because it’s dark.”
“Dark?”
“Yes-the office light is off, and the only light I have is coming in from the window.”
“Well, turn on the office light then.”
“I can’t.”
“No? Why not?”
“Because there’s a power outage.”
“A power… A power outage? Aha! Okay, we’ve got it licked now. Do you still have the boxes and manuals and packing stuff your computer came in?”
“Well, yes. I keep them in the closet.”
“Good! Go get them and unplug your system and pack it up just like it was when you got it. Then take it back to the store you bought it from.”
“Really! Is it that bad?”
“Yes, I’m afraid it is.”
“Well, all right then, I suppose. What do I tell them?”
“Tell them you’re too stupid to own a computer.”
YMMV
With so little really known about GT6 (as in only 25 people reported taking it for 24/25) it’s really hard to take a view. If it ain’t broke don’t fix it but if it’s coming to a question of stopping the riba or stopping treatment stop the riba and continue on the generic Harvoni.
Trials Data For Genotype 6
Sofosbuvir PegIFN-α Ribavirin
NAIVE
default: svr: 100%, trials: NEUTRINO 100% GT6 (6/6)
w24: svr: 100%, trials: ATOMIC 100% GT6 (5/5)Sofosbuvir Ledipasvir
NAIVE
default: svr: 96%, trials: NCT01826981 96% GT6 (24/25)Sofosbuvir Daclatasvir
NAIVE
default: svr: 97%, trials: No Trials – Based on GT1 extrapolation
YMMV
Ya, I’m not a doctor, but I gotta agree with tweakmax … Zepatier is an NS5A inhibitor paired with an NS3/4A protease inhibitor … so should maybe have an NS5B inhibitor to make it fully effective.
I am a doctor, and you are both right. Zepatier + Sofosbuvir is a sensible 3D (3 drug regimen) that targets NS3/4A, NS5A and NS5B. According to the Liverpool interactions checker there are no drug-drug interactions to worry about so it should work well.
Other 3D combinations for GT1 that can be source at affordable prices would be
Sofosbuvir + Daclatasvir + Simeprevir
Sofosbuvir + Daclatasvir + AsunaprevirThe Sof+Dac would be generic. The Simeprevir and Asunaprevir would be originator but from Egypt and Russia.
YMMV
In the graph below you will see all the results for patients on generics. The lines are the average and the size of the dot is relative to the log of the number of people with that viral load.
YMMV
Thanks GT2,
The key point is “hypogonadal”. I said <10 they used <12. We used to treat (with government subsidy) at <8 but it's been reduced to <6
Anyway step 1 remains TEST the Testosterone level.
The outcomes noted in this trial are the standard outcomes of testosterone replacement in men where levels are low. There are a few other benefits like dropping the need for Viagra and better blood lipids not mentioned.
YMMV
Please read my post about Testosterone in men here:
http://gp2u.blogspot.com.au/2014/12/testosterone-should-you-be-taking-it.html
You should start by having a morning level taken. If it’s <10 that's on the low side but if it's 15-20 that's probably normal enough.
Human Growth Hormone has been put forward as the elixir of youth and it certainly sees abuse in elite athletes as a performance enhancer. Boby builders use it with testosterone and similar steroids to bulk up. Anti-ageing gurus use it in cocktails.
The impact of HGH on health adults is largely unknown. Here is what the Mayo has to say about it:
http://www.mayoclinic.org/healthy-lifestyle/healthy-aging/in-depth/growth-hormone/art-20045735
In excess it causes acromegaly. Remember "Jaws" from the James Bond Movies?
https://en.wikipedia.org/wiki/Jaws_(James_Bond)
The actor who played that character had acromegaly from making too much HGH and his weirdly big head, hands and height were are part of the impact it has.
YMMV
OMG that’s awesome news Ariel….go you!!!
YMMV
I think a worthy goal would be to consider how people end up on her BB and look to deflect that traffic upstream of arrival.
YMMV
The second rule of propoganda is to silence all dissenting voices. Google does not, and neither does FixhepC.
YMMV
Succinct, eloquent and elegant.
YMMV
20 June 2016 at 10:20 am in reply to: Is there any evidence of DAAs impacting kidney function? #19534Hi Beaches,
This is something to watch rather than panic about. Creatinine is an indirect measure of kidney function and eGFR is calculated using a formula from this.
A good first step would be the have a urine dipstick – you should have not protein or red cells in this – if you do that needs looking into further.
YMMV
Exciting times Ariel……can’t wait to hear your great results
YMMV
[video]https://www.youtube.com/watch?v=yX6FsTIq6ls[/video]
YMMV
That was one of 2 proposals. The second one is here:
http://www.unsgaccessmeds.org/inbox/2016/2/25/andrew-hill-dr-anton-pozniak-and-dr-james-freeman
Sadly both appear to have gone nowhere.
YMMV
Past treatment (failure) is probably just another way of identifying poor levels of innate immune response to HCV – ie it picks up people with IL28 TT and probably other genes we don’t know about.
It makes sense to me that patients with high viral loads X many years = more replication cycles capable of generating resistant mutants.
Diabetes and insulin resistance is probably bad, and genotype/fibrosis.
With genotype 2 is best, 1b, 1a, then 3 last. Data for 4,5,6 is lacking. GT3 remains the problem child.
YMMV
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