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Viewing 15 posts - 1,426 through 1,440 (of 1,968 total)
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  • in reply to: More posts per page? #13287
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    There will now be 15 posts per page (up from 6) so more scrolling and less next-ing.

    It’s not a per user option.


    YMMV

    in reply to: Been offered Sof/Riba, should I add daclatasvir? #13286
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    For GT 2 the SVR is 97% on 12 weeks Sof + Riba

    The numbers for Sof + Dac are less solid.

    You sound like you have been looking at the decision support tool. http://fixhepc.com/hcv

    Put in GT 2
    6.1 in the kPa – which will set the Metavir to F0-F1
    Failed Peg Riba
    No containdications
    EASL Guidelines
    Then your numbers for platelets, weight, eGFR

    Calculate

    Scroll down and press [Show Trials]

    You can change the guidelines to see what AASLD say in their guidelines.

    Personally I would do Sof + Dac for 12 weeks and skip the Riba. There is not a huge dataset backing that yet, but it looks good and the treatment course will be milder. If I failed I would do 24 weeks Sof + Dac + Riba.

    What you have been prescribed is the standard treatment and the SVR rate is great. If you wanted to avoid the Riba you could use Dac and if you chose that I would like to add your data to what we already have because we are probably going to be the first people to have enough data to say if Sof + Dac is better, worse, or about the same as Sof + Riba for GT2.


    YMMV

    in reply to: Personal attacks on this forum #13285
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Sure thing.

    I’m locking this thread now.

    I think enough has been said.


    YMMV

    in reply to: I Live Here #13277
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Wow…jealous much :) Sounds like a little bit of heaven… :cheer: Unfortunately Bendigo doesn’t have a beach :(


    YMMV

    in reply to: I Live Here #13260
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Very nice Gaj…..do you get bothered with mosquitoes at all? Looks so serene and peaceful. :)


    YMMV

    in reply to: EOT Viral Load result #13258
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Tina I’m so sorry that the HCV has returned. Thank you for your reassurance that you may be an “unusual case”. I will be getting my SVR4 results next week…..you are in good hand with Dr Freeman as you know and I’m sure you will beat it eventually. At least there are meds out there now that are accessible and have fewer side effects. Fingers crossed for you #love :)


    YMMV

    in reply to: Indian Patent Challenge #13236
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Gilead’s phase 3 trials involved a lot of human experimentation. ION worked out well, but some of the people who helped trial telaprevir boceprevir were not so lucky. There is no evident sense of any need to pay back into the society and people that made these profits possible.

    On current trends by the time the patents on DAAs expire as many as 20 million people will have perished who could have been saved. That’s more or less equivalent to the entire population of my country.

    The US has used military force and economic sanctions against countries judged in contravention of basic human rights, and yet here we have it’s own citizens dying and it stands impotent to do anything about the actions of a corporate entity trading within its sovereign borders.

    At the conclusion of WWII a number of people, judged guilty of genocide on a mass scale, were taken out, tied to a post, and shot.

    Times have changed but we, as in society, need to have a serious conversation around pharma profits, patent rights and patient rights.

    The standard of living we all enjoy depends on co-operative effort and anybody wanting more than their fair share of the communal pie is strangling the goose that lays the golden eggs.

    FixHepC is a peaceful protest about this.


    YMMV

    in reply to: Personal attacks on this forum #13234
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    You’re absolutely right kenbasman.

    Texts/emails/posts all lose the non verbal nuances.

    It’s best to cut your losses in some circumstances. I can remember having a robust conversation with another programmer called Abigail that ended like this:

    Abigail: I am consigning you to the but bucket {kerplunk}


    YMMV

    in reply to: best method to pay for Redemption Trial from NZ? #13230
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Merin,

    We should have Credit Card facilities in place shortly but at the moment wire transfer is the way to go.

    You should be able to walk into any bank and wire it.


    YMMV

    in reply to: PBS Pricing – Take a deep breath… #13221
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    $114.90 on the PBS, or $18.60 with a Health Care Card…for three months.
    according to a Liver Specialist from Cairns who is on the Facebook.

    This specialist is out of touch. Each script is a PBS “supply” and incurs the $6.20 or $38.30 charge. So Sof + Dac + Riba would be $18.60 or $144.90 a month. Still a great deal!


    YMMV

    in reply to: I Live Here #13220
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Tasmania is a beautiful place. I lived in Glenorchy for 2 years and worked in the City of Hobart. Was living there when the accident happened with the bridge came down that’s how long ago it was. Have been back for a couple of holidays over the years too. :)


    YMMV

    in reply to: I Live Here #13219
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I was born in Hobart but have spent half my life in far flung regions from Sydney to London, Guadalcanal to Cape Town.

    I’ve lived in big cities and small towns and prefer something in the middle.

    I’m like a penguin coming back after a year at sea.

    Every time I return the smell of the place makes me feel like I’m home

    hobart-at-night.jpg


    YMMV

    in reply to: Personal attacks on this forum #13167
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi DT,

    Thanks for posting.

    Having read the thread I can see how you might feel that way.

    To me your question was perfectly valid and Sir’s response was rude. We all have bad days.

    That might well have been the end of it but you did then throw a rock back with:

    Hi Sir,

    Have you just caught up with this conversation? – a day late and a dollar short, as they say.
    Maybe get yourself into the ballpark first, then we’ll have something to talk about.
    dt

    And it looks like the bickering continues from there. Sir did have a valid point in that not detected does deserve a dancing banana.

    #woohoo!

    To answer the original question:

    I’ve now seen well over 2000 HCV RNA results from almost every lab in the country.

    Some report at HCV quantitative like this

    HCV RNA <15
    log < 1.18 And then go on to add: Comment: Undetected (by mostly COBAS Taqman) Some report it like this: HCV RNA N

    N = Undetected

    Some like this:

    HCV RNA < 15 COM1

    COM1: Not detected

    There are quite a few styles and skipping writing <12 <15 <25 or <30 when it is undetected is not that uncommon.

    Undetected itself really just means <5 (depending on the test).

    I did see one the other day that said something like "Quantification not done due to HCV RNA not being detected" which seemed a pretty sensible way to report it.

    Personally I prefer the ones that cut to the chase and just say undetected rather than requiring me to read the <15 and then the comment.

    Anyway, I think you've been here long enough to be made a moderator too so take care with the extra buttons. The pay is terrible and the hours are awful.

    We're a mixed bunch and it's highly stressful wondering if you're going to draw the short straw at SVR time. I've enjoyed a lot of your posts and would hate to see you go or not feel welcome. Maybe you and Sir could agree it was not the finest hour on the forum and both decide to move on?

    I would be willing to bet that if you and Sir did the personailty test here:

    http://www.humanmetrics.com/cgi-win/jtypes2.asp

    You would fall at polar opposite ends

    Me, I'm an INTP

    INTP
    Introvert(38%) iNtuitive(62%) Thinking(53%) Perceiving(34%)
    You have moderate preference of Introversion over Extraversion (38%)
    You have distinct preference of Intuition over Sensing (62%)
    You have moderate preference of Thinking over Feeling (53%)
    You have moderate preference of Perceiving over Judging (34%)


    YMMV

    in reply to: Melatonin #13163
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    The correct dose of melatonin is 2-6mg 1-2 hours before sleep is desired.

    It is made in 2mg and 3mg tablets.

    Homeopathic melatonin is water so don’t bother.

    Here’s a post of mine about insomnia: http://gp2u.blogspot.com.au/2015/02/how-do-i-fix-my-insomnia.html


    YMMV

    in reply to: End of Treatment day #13158
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Great day for you Pat…………..now the wait for your SVR’s. It’s a bit surreal not having to take the meds every night. :cheer:


    YMMV

Viewing 15 posts - 1,426 through 1,440 (of 1,968 total)