You or the prescribing doctor should confirm details with the compounding chemist but usually they use the drug name rather that brand name so:

Sofosbuvir x 400mg x 1 daily x 4 weeks (28 days)
Daclatasvir x 60mg x 1 daily x 4 weeks (28 days)

Coffee is a weak ‘inhibitor’ so unless you are drinking large quantities (or are very light weight) it probably won’t have much effect though would be easy to reduce for a couple of days to see what difference it makes.

Something else I should have mentioned is that most of us find that being well hydrated helps reduce any sides so drink plenty of water through the day but if these problems continue to worry you should discuss them with either your clinic or a doctor with experience with HCV.

Congratulations on reaching SVR24, wilco johnson (the other one )!

Hi Edge and welcome,

Great to hear that you’ve started treatment and that you are sleeping better, much easier than the old treatments isn’t it?

As Tommy says, plenty of fruit and veggies (and water) will help your liver but you may have a point about the salads particularly if you were previously eating a heavy meal late in the day. I’ve been doing a bit of reading lately about how circadian rhythm effects our liver. It seems what and when we eat determines how well our liver works and it seems to make sense that a happy liver at night is more likely to result in good sleep. I am now trying to eat well earlier in the day and avoid the temptation of snacks late in the evening and seem to be sleeping a bit better myself.

Clock dysfunction accelerates the development of liver diseases such as fatty liver diseases, cirrhosis, hepatitis and liver cancer, and these disorders also disrupt clock function. Food is an important regulator of circadian clocks in peripheral tissues. Thus, controlling the timing of food consumption and food composition, a concept known as chrononutrition, is one area of active research to aid recovery from many physiological dysfunctions.

https://www.ncbi.nlm.nih.gov/pubmed/26907879

Hi chongandco,

I’ve sent you a PM.

Hi Han,

Please see Dr Freeman’s explanation in the first post of this thread. In summary, taurine is an essential compound as you say but it is also an inducer of the CYP3a4 enzyme which is what metabolises Daclatasvir. That means that increased levels of taurine increase the rate at which Daclatasvir is removed from our bodies therefore reducing its effectiveness. So while we need taurine to survive and it is a natural part of our diets, we should not add extra via supplements or energy drinks during treatments that contain Daclatasvir. An example where ‘more’ doesn’t necessarily equal ‘better’.

Bristol-Myers Squibb who make and license Daclatasvir have recognised this is a potential issue per below quote and link.

In addition to herbal and dietary supplements which may increase DCV exposure via CYP3A4 inhibition, others may induce or modulate the induction of CYP3A4 and thus potentially reduce the antiviral activity of DCV. Such extracts include St. John’s wort (Hypericum perforatum; a strong inducer of CYP3A4 and thus contraindicated for concomitant use with DCV) [36] and taurine (commonly found in body-building supplements and energy drinks) [38].

http://link.springer.com/article/10.1007%2Fs12325-016-0407-5

Such good news to read.