Hi CD,

Great news to hear that you have found a doctor willing to help.

Just to clarify the situation a bit, as splitdog says this is the Sofosvel thread about Beacon Pharmacueticals new Velpatasvir/Sofosbuvir generic which is manufactured in Bangladesh. The prices are only the cost of the medication excluding shipping.

The Redemption eTrials details can be found here https://fixhepc.com/redemption-imagine-freedom-from-hepatitis-c along with current pricing. These trials use the Indian licenced manufacture version of the generics, either Harvoni® or Solvadi® + Daklinza® depending on genotype plus they include freight costs, delivery guarantee, etc (plus back up and medical support from MonkMed if required) thus the higher pricing.

An email to help@fixhepc.com should result in answers to any more detailed questions you have regarding Redemption.

Thanks,

Yes, early trial, small cohort and no placebo.

I went and had a quick look at just the diarrhoea results for Vox trials I could quickly access and the figures are all over the place. NCT02378935 was 9.6%, NC02378961 was 22.7% Both were non placebo trials. Interestingly I found an (admittedly phase 1) trial that used placebos NCT02185794. The placebo arm had 12.5% whereas the drug arm was only 5%.
The problem with quoting small scale trials which contain no placebo arm like you did is that anytime that you get a group of people together for a period of say 12 weeks and ask them to report adverse events, diarrhoea and nausea are going to show up fairly regularly whether those people have HCV or not and whether they are taking drugs, placebo or nothing at all. They are really common symptoms of everyday life that vary from location to location and season to season so you do need to be extremely cautious about attaching significance to them particularly if there is no placebo arm to the trial.

I would also suggest you reconsider your “no sides for vel” statement. See p91 (onwards) below which shows them plus whether they were considered relevant. This is why we need placebo arms, to determine whether reported sides are related to the drugs or coincidental.

http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/004210/WC500211152.pdf

Hi PKQ,

A biopsy is the definitive diagnosis for cirrhosis, at least for the area they took the sample from so if the surgeon stated he found it then the only argument is over what is going to happen next and it sounds like he has lost that bet. The good news is that the liver is an amazing organ and in many but not all cases once the cause of the cirrhosis is removed the liver is able to regenerate. The extent of regeneration will vary from person to person depending on any number of factors such as diet, lifestyle, your genetics and how bad and widespread the original scarring. When that occurs it should be possible to live a reasonably normal, healthy lifestyle afterwards.

But you need an answer as to what condition your liver is in now. The surgeon who diagnosed your cirrhosis put you on a liver transplant list so that is your first port of call. The lists are far too long for the number of available livers so if he can safely take you off that list he will be absolutely delighted to do so even if his previous bedside manner seemed like a used car salesman trying to make end of month targets and he shouldn’t need another biopsy to do that.

Failing that, as the others said Fibroscans are available even in some regional centres these days though you will probably need to book ahead by a couple of months. The bush is a big place so if you can give us a better idea of which bit someone here may be able to suggest a suitable option.

I think Dr James has already made an approach hasn’t he?