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Paul-Jarman-facebook wrote:Price wrote:
Gaj,
http://hepatitiscnewdrugresearch.com/fatty-liver-and-hcv.html
Reducing dietary saturated fat is associated with an increase in LDL-receptor abundance (which helps the virus multiply) of magnitude similar to the decrease in serum LDL-cholesterol (which is what happens with geno 3).
So it looks like your new diet will have to include restriction of PUFAs in favor of big fat steaks, and eggs and bacon for breakfast instead of cereal, butter, coconut oil ick:' /> ….and treat during winter when chol is higher (because of seasonal variations in bile acids).
P
So no carbs, more greens and animal fats/protein ?[/quote]
Hi Paul,
Thanks for your thoughts. More a case of low carbs and sugar, more greens and use animal fats for most of your energy requirements. Here is a link to a post by Dr James about this sort of thing. https://fixhepc.com/forum/supplements/566-supplements-the-ketogenic-diet-and-hcv-viral-load.html#7463
In there you will see my post about my diet at the time which I have now modified a bit to reduce my carb/polyunsaturated fatty acid intake and increase saturated fats (but not hydrogenated) for energy. Pizzas are off the menu now. But on the bright side, lots of steaks, untrimmed lamb chops , bacon n’ eggs, butter and goodies like that plus non-starchy vegs. Will have to start working up some Thai style curries with coconut cream but skip the rice accompaniment and add vegs instead. (Read Price’s post as cereal being the only bad one in her list) The Hopefulgeranium blogs in Dr James post are an interesting if sometimes heavy read on the subject to give some guidance. Look at limiting the hours when you are allowed to eat too so you are in a fasting mode for longer each day, so no midnight snacks, etc.
But for those fearful about Gaj’s arteries please be assured that a) I am following this diet with a little bit of moderation so have just moved the balance further away from carbs and over to saturated fats than I usually would eat. b) It is intended as a HCV treatment diet until I achieve SVR not a lifetime plan. (I love pizza far too much to live out my days so miserably. )
Regarding fatty liver and fibrosis, etc. any exercise is good but from what I have been reading lately vigorous exercise really helps but make sure your doctor gives the go ahead first. Yeah, I know, not so much fun for us whose natural inclination is to be couch potatoes (joke) but if it helps then so be it! And thinking about this, do you remember member Bloot? From his tales he had often led a dreadful lifestyle for someone with HCV but his liver was in pretty good shape. Well he was also a very keen and active mountain biker so that is starting to make sense to me now.
Hope all that makes sense. Take care and best wishes for your Tx.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Sven wrote:Alpha Lipoic Acid: I did too, please let me know ASAP if we can or cant during treatment.
Thxhttps://fixhepc.com/forum/supplements/534-supplements-with-evidence.html#6869
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi fitz and Meg,
Thanks. I mostly agree with both of you. This site does allow and encourage discussion about all the various aspects of HCV and its treatment including new developments and theories. Some of which are well ahead of currently accepted treatment practice.
As a result I do believe that we should always remember that we are not just discussing these issues as a small group of like minded individuals in a private chat room where everyone will immediately understand the theoretical discussion and the consequences of any actions we as individuals take. We should keep in mind that we do have an international audience many of whom may not be fluent in English and as a result are using either the language translator built into this site or Google Translate or similar. Most of these translators give a rather literal version of what is written and may not adequately cover the context of the discussion. Occassionally the translation can even be the opposite of what we really mean. Also sometimes people may not read the full thread from start to end so may miss important bits of information.
The same sort of thing applies with links to information on other sites. Please don’t just assume that because it is a reputable site the information is correct, they can still make mistakes. Please check thoroughly before you post the link.*
With those points in mind please ensure that our larger audience is always aware that topics such as being discussed here are your own thoughts and frequently remind anyone thinking of following the same path that they should always seek expert medical advice before doing so.
Thanks in advance.
*Remember the old joke quoting Abraham Lincoln as saying “You can’t believe everything you read on the Internet”
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Jeanmarc,
Sorry to hear that you appear to have relapsed as did I recently. As the others say, there are new medications becoming available but my advice would be that your best option is to consider arranging a Skype or telephone consultation with https://gp2u.com.au . They are up to date on latest treatments and will be able to provide sound advice regarding whether you should retest your viral load as a check and also probably to have a new genotype test to confirm correct treatment going forward.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Okay, I really need to emphasise some caution here.
My chemistry is a little bit rusty but please note that the product that has just been linked does not appear to be Chlorcyclizine.
Chlorcyclizine = 1-[(4-Chlorophenyl)(phenyl)methyl]-4-methylpiperazine
However the product that is linked to is listed as:
Chlorpheniramine = 4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
I fully understand everyone’s enthusiasm for clearing this horrible virus from our bodies and indeed feel the same way. However this thread appears to be getting perilously close to advocating use of medication combinations based on media reports and the third hand retelling of the private musings of researchers and doctors……it concerns me that this may put readers at risk so would suggest that perhaps it is time to take a step back and seek expert advice?
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hazel, congratulations!
So happy to hear your good news, it must be a tremendous relief after your recent wait.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Welcome Lisa,
I agree with sonix. Without knowing why you are taking the protein supplement I would advocate thinking about stopping it for the period (12 weeks?) of treatment and you can then start again if you want after finishing. Apart from the enzyme powder it also includes things like yucca which I’m inclined to think would not have been researched for any potential interactions. But noting that it could also be yuca (cassava) as the spelling sometimes gets interchanged which is part of the problem, just knowing exactly what is included. If absorbtion/digestion problems due to cirrhosis or similar are why you take it you may find that those are much improved on commencement of treatment, they certainly were in my case.
As noted it needs to be either Hepcvir-L (or plain Hepcvir in combination with a second drug)
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
DO NOT take this without consultation with your doctor.
Thanks sonix, that is excellent advice.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Tweakmax, they are not just talking about Hepatitis C but all viral hepatitis types. Targeting about 400 million people over the next 14 years.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi all,
Please note that Cetirizine Hydrochloride and Chlorcyclizine are not the same drug even though they are both antihistamines. They may be reasonably interchangeable for sinusitis but probably not for HCV treatment.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Well, that is 10% in just over four months. I reckon the Gilead bean counters may be rechecking their sums if we are only paying them for 13,000 per year.
No generics in those figures, they are based on PBS prescription numbers.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
NOhep is also launched today.
“NOhep is a global movement aimed at uniting those working in the field of hepatitis and others from across the world around one common purpose: the elimination of viral hepatitis by 2030. NOhep is calling on individuals and organisations across the world to sign-up to be part of the next greatest achievement, the elimination of viral hepatitis.”
You can find out more and join up here:
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Pharma’s Market updated.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Some from Australia:
http://www.ashm.org.au/Pages/World-Hepatitis-Day-2016.aspx
http://www.hepatitisaustralia.com/whd2016/
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Thanks RHF, with the slight caution that the 95% SVR is the overall result for all G3s. Previously relapsed patients and those with cirrhosis don’t quite acheive that level. But it does look like a promising option.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
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