Beacon’s Pharmas Market page has been updated to their new web address: http://www.beaconpharma.com.bd

Hi Skank,

I’ve removed your other post from public view and forwarded it to Archer as a Private Message. You can also send PMs on this site by clicking on the little blue speech bubble at the bottom of the side panel with their user name and other details to the left of a member’s post. You can read PMs sent to you by clicking on your own name to go to your profile where you will find the link in a similar spot. Or via the link just under “Glossary” in the row of tabs at the top right of each page. (If that isn’t showing click on the little blue tab to the right of the “Glossary” one.) Hope that helps.

Hi Price,

There didn’t appear to be a lot of correlation between this post and genotype 3 relapse and retreatment options with DAAs so I’ve split it off into its own thread.

Hi flyingfox66,

I’m sorry to hear you are having issues post treatment. None of my post was in response to yours as I am not qualified nor have the experience or knowledge to to make suggestions regarding your particular symptoms.

However, I do have experience of disbelieving doctors as I am sure do many others here. My suggestion based on that experience would be to seek another, more empathetic opinion.

Edit: beaches probably states it better than me.

No, he did not! He stated “since it is a 5Fluoro-Uracyl -like compound”

“Is” and “like” are not interchangeable words particularly in this sort of discussion.

“Sofosbuvir is a phosphoramidate prodrug that is metabolized in the liver to β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine-5′-monophosphate.”

https://www.dovepress.com/changing-the-face-of-hepatitis-c-management-ndash-the-design-and-devel-peer-reviewed-article-DDDT

I just want to make sure that readers realise that while the above quote and citation are fine they are not attributable to A. Ponzetto.

Knowing exactly what you’re taking can help prevent, identify and treat side effects. For example, the literature says that skin redness can be helped by Pyridoxine (Vitamin B6). Obviously, everything should be checked with your doctor.

https://books.google.com/books?id=CDADMzS0TKUC&pg=PA161&lpg=PA161&dq=5FU+and++cutaneousYHXuc2V0&hl=en&sa=X&ved=0ahUKEwi5qqnnhJLOAhUUT2MKHc4fArwQ6AEISTAG#v=onepage&q=5FU%20and%20%20cutaneous%20toxicity&f=false +toxicity&source=bl&ots=dNje7r1NGT&sig=RhgFPgLWtnXjAHO_po-

Very true but “knowing exactly” is the important point and Sofosbuvir is not exactly 5Flouro-uracil so you should not be extrapolating treatment from one to the other. Your advice about checking with a doctor is sound.

I would also like to point out that in your original citation A. Ponzetto goes on to comment about the toxic excretions of bacteria (h.pylori) that at least 50% of the human population carries in our digestive systems and also about the levels of chemotherapy type molecules in the food and water most of us eat and drink. My reading of that is that he is not trying to scare us but to point out that many items we ingest carry some very, very small element of risk but many benefits and Sofosbuvir fits in that category.

We know that Sofosbuvir may have some side effects and very occasionally a patient may have more serious adverse events, that has been well documented. However, it does not mean that every event that occurs while on treatment relates to that treatment. In JamesF’s instance he has a reddening of the skin, it may be from Sofosbuvir but then again millions of people worldwide get rashes everyday without taking Sofosbuvir. He has wisely sought medical advice and both his specialist and Dr James have suggested monitoring as appropriate at this point, I’ll back medical opinion.

Thanks RHF, a great post on what is an important subject that I suspect will become more so as greater numbers of people receive treatment and attain SVR. I have said on a number of occasions that the best way to help end the worldwide HCV pandemic is to break down the stigma associated with the disease. Currently the general public has very little idea about the disease, the number of people impacted or the injustices perpetrated by big pharma greed.

In my case I made a decision last year when I started treatment that I would disclose my status at my own discretion as part of the education process (and to some extent because I decided it was easier than not doing so). As a result I have told all my friends and many of my associates and have given most my permission to pass on that knowledge at their discretion while explaining that I trust them to do the right thing. And like you I find many are curious and wish to know more about a disease they often think is incurable. At the same time I am not yet comfortable disclosing on social media where I have no control of how it is spread or construed. So on here and other sites my public face is Gaj although those who have had private conversations with me will know that I am happy to use my real name in those situations.

Also like yourself, something that has come up several times while disclosing to others is that they have then said “Oh, ‘mutual friend’ has Hep C too”. My response has been to ask if the friend has given them permission to disclose that information while at the same time pointing out that my status doesn’t constitute that permission, but I then tell them they can inform our friend of my status and to ask him/her to contact me if he/she is interested in learning more about seeking treatment.

What I’m trying to say here is that while I fully support and encourage disclosing of HCV status to help spread the message to others, it must be our own choice as some of us are better prepared/equipped than others to fend off any potential stigma that may ensue for ourselves and possibly our loved ones. We need to make the decision ourselves and ensure it only applies to ourselves unless we have been given permission by the other person.