Forum Replies Created
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Fantasic news LG! 
It’s so good to see that UNDETECTED in your signature at last.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
The “in inflammation-driven models of fibrosis” part of the original text is important to context.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Sorry to hear of your friend, it must be so difficult being stuck in that situation. While DAAs themselves are unlikely to reduce fibrosis on their own, there is considerable research and clinical trialling going on of other medications that do target fibrosis reduction in the liver and other areas. Some of the research and trials are quite advanced so hopefully we will get some good news soon.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515973/
https://www.monash.edu/__data/assets/pdf_file/0008/376838/Anti-fibrotic-drug-development.pdf
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi beaches,
My reading of the available evidence is that the DAAs remove the HCV and the absence of HCV reduces inflammation. Inflammation is what causes fibrosis and eventually HCC. So if inflammation is reduced and fibrosis is not being created then the liver has a better chance of regenerating and there is less risk of HCC forming. If you have enough healthy liver to currently support you then there is an opportunity for it to regenerate. The problem is when your liver can’t support you from day to day, at that point you need a transplant anyway, although no longer having HCV thanks to the DAAs means your new liver won’t get infected.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
DAAs must inactivate CB1 because receptor CB1 is crucial for fibroblast activation.
No, there is no evidence of inactivation of CB1 by DAAs. There is evidence that DAAs destroy the Hepatitis C Virus and that the absence of HCV reduces up-regulation of CB1.
Inactivation of CB1 exerts potent antifibrotic effect.
No, but there is evidence that “CB1 inactivation has been shown to inhibit the progression of fibrosis” which differs from your claim of a potent antifibrotic effect.
On the other hand Hepatitis C Virus up-regulates the Cannabinoid Receptor 1
Agree. See point 1 above.
I’ve seen one case of Peyrone’s caused by interferon.
Err, no. I suspect you have seen one case of Peyronie’s disease coincident with interferon use and have jumped from effect to cause. Available scientific evidence is currently contradictory regarding any link to something that effects up to 5% of the male population anyway.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Lower case w in #woohoo!
Congratulations! Onwards to SVR.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Great news beaches!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Bump!
As a reminder for all new members and guests above are our thoughts on verified sources of medication as stated in the Pharma’s Market section of the site.
For information about other distributors and resellers please read below links into the Distributor’s Market section.
http://fixhepc.com/forum/distributor-s-market/957-distributor-s-market-reasons-rules-warnings.html
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Greedfighter,
Just as a word of caution for our readers when looking at the prices quoted by hepcasia.com, we need to remember that they are based on “community procurement costs” in Delhi and N. India. They are best available pricing structure to those who have the right contacts and connections……and possibly volume of prescriptions. So they are a guide to what is possible for those living in some parts of the Indian community but the cheapest prices are unlikely to be readily available to medical tourists or mail order.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Dr James,
Fixed! I wish I was that clever, but there’s good reason why Oor Wullie is the leader of the gang.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi beahaven,
I have moved above post to a more suitable section.
$1495 is around the price that is being quoted by others for Harvoni from India but with shipping included. So paying an extra $917 for the shipping doesn’t sound like a great deal to me.
I would also be concerned about buying Harvoni from an “Indian Pharmacy” whose website is US based with a hidden country of origin and a PO Box in Panama as their contact address.
When sourcing medications like Harvoni you need to have confidence in your supply chain, please read this link: http://fixhepc.com/getting-treated/supply-chain-integrity.html
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Congratulation!
Best wishes for SVR.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Congratulations Phoenix! Great to hear of your SVR5 and hope your cold goes away soon so you can really celebrate.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Thanks Serg,
I also see on the same page a report about vitamin D supplementation reducing the presence of NS5A RAVs.
SAT281
LOW SERUM 25(OH) D3 LEVEL AFFECTS THE EXISTENCE OF DRUG-RESISTANT MUTATIONS AT THE NS5A REGION IN PATIENTS WITH CHRONIC HEPATITIS C 1B
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Serg,
Are there any links available to the report? I haven’t seen any studies published previously about effects of IL28b gene on DAA response.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
