Forum Replies Created
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Hi LG,
Sorry to hear that you are under the weather. It doesn’t sound like sides with the cough and stuff so I think you may have flu or whatever bug is going around over there now.
For antibiotics if necessary, just take a link to http://www.hep-druginteractions.org/checker to your GP with you. Either on a phone or print out the link on paper.
Get well soon!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Demian and welcome!
Difficult to say. Probably best to contact the four Russian forums linked In the first post of this thread for that information.
The FixHepC site has information on a number of sources in the below linked section of the forum, it is for information purposes only.
http://fixhepc.com/forum/generic-medication-access-channels.html
Please ensure you read the below thread listing the ones that have been investigated that we have confidence in.
http://fixhepc.com/forum/daa-access/457-warning-to-online-buyers.html
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi psavic,
Congratulations on you negative/undetected result!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Ahaa! Thanks Price, I’ve created the correct shortcut.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi dt,
My understanding from Thurl’s question was that he was referring to long term maintenance dosing of Sofosbuvir rather that short term curative monotherapy testing as Gilead did with during Electron. I was responding to that when I stated that no research or trials had occurred to my knowledge.
I had already stated my concerns about long term maintenance use of Sofosbuvir due to some potential for resistance development. And that is because Sof is the ‘keystone’ of many of the most effective HCV therapies at the moment when used with another DAA. Yes there are alternatives but they tend to require 3 or 4 drug combos for less efficacy and more sx.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Good question Thurl,
At the moment I suspect the answer is that no one knows because because as far as I know it hasn’t been researched let alone trialled. The focus has been on curing not ‘maintaining’.
There has been some mention of HIV and the use of retrovirals but what has to be remembered is that in that case there isn’t any cure. However, in the case of HCV we now have treatments that cure the vast majority of people first time round. That leaves a few percent who need pretreatment and the majority of those will clear on their second attempt and if you are one of the very, very tiny percentage who don’t clear after two tries then there will probably be new drugs to try by then given that getting that far will take you a fair while. So my question would be why would you want to effectively ‘warehouse’ yourself and wait indefinitely…..and for what?
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Jade and welcome,
Always nice to hear from the US. If you want to, please feel free to start a thread to post about how you found the site and also how you sourced your medications. I’m sure there will be many of your fellow Americans who are interested to hear you and your husband’s experiences to help them understand the process better.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Reading the article, Dr. David Shulkin from the VA seems to assume that the horse has bolted and can’t be caught?
Oh well, he can probably close and lock it so the next one doesn’t.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
I suspect that some of the lack of comment is due to the few who have so far completed treatment mostly still awaiting their SVR results. In my imagination I can see that wait taking forever when it becomes my turn and wonder how I would comment on that at the time?
……but then again, I was always awake by 4am on Xmas day and talking to my brother about the anticipated presents, even though we weren’t allowed to get out of bed and start unwrapping until six!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Valerie,
Per Tina’s comment, scroll to top of this screen and click on the ‘Private Messages’ words on the right hand side.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Chejai,
If using the capsules via Buyers Club then my understanding is that there is no lactose or other incipient used, just pure Sof, Dac or Led. That is why the capsules aren’t quite full.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Agree dt,
UND doesn’t mean ‘None there!’, rather it is ‘I can’t see any?’.
and the test can’t determine whether the RNA it can see is viable or not which is why some who are still detected at EOT go on to a SVR.
Then there is the question of whether some who ‘relapsed’ may have actually been reinfected post treatment?
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
On the other subject of using Sofosbuvir as a prophylactic until something else comes along, probably not.
The “nuke” that Prof Gane is referring to is indeed Sofosbuvir which is a “Nucleotide analog”. It is fairly unique in the way it operates as it effects the HCV virus at two points. This does make it fairly immune to resistance but not totally so. So long term use as is being proposed could result in resistant strains developing.
As others have commented, we can currently retreat by hitting the virus with the same meds longer and harder, or we can test for what the resistance is caused by and then select an alternative DAA that acts on different pathways. Or failing both those options we probably need to wait for a new drug to be developed that will be effective against our resistance strain. But that is happening fairly regularly these days as we understand better and better how HCV works and what is needed to stop it.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
I haven’t seen anything in this thread that covers much ground that wasn’t covered previously. Prof Edward Gane is a brilliant and well respected Hepatologist and researcher. He was instrumental in proving the efficacy of many of the DAAs that are now available and my understanding is that also includes many others than those patented by Gilead.
As to why he isn’t proving the efficacy of generics? Why the hell would he? That isn’t his job! He already has quality, proven DAAs that he was involved in the proving of and so has confidence in for his patients and others to use around the world.
What you guys are doing is asking the developer/tester of a Mercedes (which is admittedly priced like a Rolls-Royce) to test and prove and state that a Honda is just as good!
I will state this again: –
If you do not want world leading and professional Medical experts involved in researching and proving new medications, then don’t expect many major breakthroughs in the future!
Okay end of
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
I’ve experienced the same issue with ‘greyed out’ screen, or just a random request to relog in over there, both on Volleyboss’ forum and the other one. I thought it was just because I was using a tablet but maybe a glitch in the Delphi software?
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
