Forum Replies Created
-
No credit cards! Bank transfers only?
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Well, capitalism is to be expected with a new marketplace developing. That may not necessarily be a bad thing if it spreads the word and gives people confidence to buy from a ‘local’ source rather than trying to negotiate the intricacies of the Indian/Chinese/Bangladesh markets. And no doubt competition would eventually make the pricing more realistic.
But that site doesn’t exactly inspire my confidence with its errors, typos and “don’t contact us, we’ll contact you” approach.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
You should be fine Paul, coffee is a substrate that has no effect on Dac (phew!) and later research on garlic shows:
“Exposure of hepatocytes to garlic extract may reduce the expression and activity of CYP2C9 with no detectible effects on CYP3A4.”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951329/
Just avoid the top four fruits on that list where possible and definitely don’t wash the Dac down with a glass of grapefruit juice.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Phoenix,
Just realised I haven’t even said hello.
Congratulations on starting treatment!!!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi DorianLS,
Inexpensive is good but only if you get what you paid for and in a timely manner. Please see the below post.
http://fixhepc.com/forum/daa-access/457-warning-to-online-buyers.html
As and when others are recommended and verified I would imagine the moderators will add them to the list but the operative word remains confident.
must post faster…..thanks Paul! 
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
sonix wrote:Even cannabis is not contraindicated and I can vouch it helps with the common sleep deprivation many people here have reported,
Hi Sonix,
SSshhh! You’ll get some of the others grumpy with me for recommending against it in another post somewhere around here.
Actually my reasoning for doing so is that it is an inhibitor although relatively mild. The problems are that you never know what the size of your dose will be (not just talking stoned vs wiped but also the various levels of different forms of cannabinoids in each dose) and also being absorbed by fats it hangs around in your body for several days to weeks afterwards. Plus the other chemicals from smoking it that your liver must process. So I figure that for 6 months I can add that to things like alchohol that my body will survive without. And probably thank me for not adding to its workload while healing my liver. And you specialist/GP can prescribe what are probably more benign sleeping aids if necessary. Of course YMMV.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Whoops! I just saw the comment about avoiding everything on the substrate list….that may prove a bit difficult as substrates are the things that the enzyme works on such as Dac and many other things we ingest. Just avoid the potent inhibitors/inducers and check for substrate clashes via the drug interaction charts.
PS BMS may not have listed things like Pawpaw because it is not common in U.S./Europe or they may have checked it and found that the inhibiting it does doesn’t impact Dac due to the chemical pathways involved. Best to be cautious with things like that but they will have checked many common items and do not see them as an issue. Ginko and Ginseng are listed on the drug interaction charts though.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Phoenix,
We need to keep in mind that CYP3A4 is one of our more important enzymes so pretty much anything we ingest is involved.
We are only concerned about potent inhibitors or inducers. So yes, per the cited article Star Fruit, Paw Paw, Pomeganate, Grapefruit are all inadvisable as are things like Echinacea, Ginko, Soy and Grape Seed extracts. Also keep in mind that these are inhibitors so will result in slower metabolisation of Dac. i.e. They will tend to retain Dac in our bodies for longer which could caused too high levels and sides.
OTOH St Johns Wort is an inducer so it causes our body to lose the Dac too quickly and is therefore an even bigger problem as the Dac may get removed before it does its job.
Garlic apparently does both so a bit difficult to determine effect, but would be warned against by BMS if it was potent at either. I would suggest a bit of garlic for flavour won’t have any effect but eating cloves of raw garlic, particularly within a few hours of when we take our meds is probably something to avoid.So basically avoid items listed as potent inhibitors/inducers and for mild ones don’t consume in large quantities or at the same time as you take the Dac.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Phoenix,
Thanks for the tip about pomegranate and noni juice too!
I was also told that Seville Oranges and marmalade made with them should be avoided during my 2013 trial.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Substrates of CYP3A4 are the drugs that are metabolised by it. The inhibitors and inducers are the chemicals/drugs that effect the rate of metabolisation and are the ones we want to avoid. The link gives a reasonable explanation.
Daclatasvir is one of the substrates of CYP3A4 as are the others Phoenix listed. Now, two substrates at the same time can effect how efficiently CYP3A4 works if one is monopolising the enzyme but we just need to check the drug interactions chart which should pick those up.
http://www.straighthealthcare.com/cytochrome-p450-3a4.html
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Enkel wrote:M
the value of Zhuk should be 0.5, it is impossible to be 5
Hi Guys,
I suspect your results are per decilitre? Zhuk’s, like mine will probably be per litre. So yes, what you would call 0.5 is 5 in Australia.
I often need to convert when comparing results or using things like MELD calculators.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi zhuk,
About time you joined in!
I must say your stats look good and agree the odds are definitely on your side.
Start mowing them virions down!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Yeast spreads such as Marmite do have added B vitamins including B12 and folic acid.
https://en.m.wikipedia.org/wiki/Marmite#Nutritional_information
And for Aussies there is Reduced Salt Vegemite (normal Vegemite doesn’t have B12 added)
https://www.vegemite.com.au/products/vegemite-reduced-salt
Probably not enough if you are seriously deficient unless you eat them by the spoonful but will supplement to other sources.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Jumping Jacks! Yes, they are nasty little buggers. There is a nest in the creek reserve that my place backs onto but fortunately they stay on their side of the fence.
https://en.m.wikipedia.org/wiki/Jack_jumper_ant
While I usually say live and let live, if these are in an area of your property that you use often you may want to consider exterminating the nest.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Barry,
While not strictly retreating with DAAs per your question, I was part of a 2013 trial with Peg/Riba + Daclatasvir for 24wks. Relapsed straight away at EOT. Early in 2015 tests showed me at increased risk of HCCs and one was picked up in late April and I had segment 5 resected early June. Then in Nov I had a RF ablation of another HCC in segment 6. I’m currently six weeks into 24wk Sof/Dac/RIBA retreatment which I expect will clear me of the hep c. Worst case, my specialist tells me, the reduced activity of my liver not having to fight the virus so hard will reduce the risk of further HCCs during that period and maybe new and even better drugs already in development will become available.
I agree that your specialist meeting in September was less than ideal and you should have been called in earlier although they may have been “waiting to see” given the initial detect was so soon after EOT. Also, something I have discovered in the last 12 months is that cancer is a emotion driving word. You can see its impact on everyone when the subject comes up, often with the ‘shutters’ coming down even when people do know what to say to you…..and the medical profession are no more immune than anyone else. Many of their patients don’t want to know and/or need support and hope rather than total honesty, but if you are in the latter group you need to make sure that your treating doctors understand that and are aware you want any new information asap and they are reasonably comfortable with providing it.If you can provide some details of your prior history and treatments in your signature panel that will also assist people to answer any questions you have. Scroll to the top of the forum page and click on Profile tab, then click Edit and enter your password twice, then the Profile Information tab and scroll down to the Signature panel at the bottom of page.
Best wishes
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
