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Ah, so eating the pawpaw on my kitchen bench and the miso (soy extract) in my fridge gives me a higher dose of Dac for free! Maybe I should tuck in until I get bad sides!
ick:' />Thanks Mike. Love the pic and the avatar!
The article states that Gilead does hold a China patent for sofosbuvir. If that is the case, how can Mesochem make and sell its generic sofosbuvir for a bargain price?
Given that the doctors I’m asking to write a script, in the town where I live, probably won’t have written a private script for these medications, I’m wondering if they might need some guidance as to exactly what to put on it. Given that I’ve failed boceprevir / interferon / ribavirin, and didn’t tolerate it well at all, it looks like the best regime for me is probably Sof + Dac 12 weeks. Mesochem looks like my preferred supplier through the Buyers Club. So what should the doctor put on the script for Mesochem – “12 weeks”, a certain number of grams for each, something else?
I have to say the discussion forum is working very well for me as it is. A bit of browsing and I feel I’m finding everything I need.
I’m still a bit confused on this topic. I’ll summarise what I’m perhaps understanding:
1. At present the new HepC drugs are not listed at all, so they are not S100 medications. Therefore, right now, any medical practitioner can legally prescribe them.
2. If the drugs are listed in November, they will be S100 medications, and thus prescribing of them will be greatly restricted.
3. Therefore, if you want to get a prescription for the drugs now to use for the Buyers Club, it’s best to do it before the end of November, because any (kind and brave) doctor can do it now, but that might not be the case in December.Is all of this correct?
How about side effect profiles Ledipasvir vs Daclatasvir? Which one is most likely to have minimum effects so that I can work through the treatment?
If I allow myself to inhabit the part of me that doesn’t want to wait… I feel stronger. I feel in charge of my destiny. Not a victim of the villainy of pharma and a government that values patent over patient. I am actively claiming a new life now.
I have low fibrosis – after probably 38 years with this disease my liver is apparently almost normal. But am I “well”? Hard to say. What is “well”, as I’ve never had an adult life free of this disease. I’ve had years on a disability pension due to overwhelming fatigue. I overcame most of that with diet, meditation and Cathay Herbal’s CH100, and I’ve been working again continuously since 2006. But I’ve had to drop back to part time the last few years. After 3 days work I’m knackered. For decades I’ve needed to go to bed by 9.30pm or I’m tired the next day. My diet and stress levels have to be absolutely right or I crash. I’ve had a very stressful work situation for the last 2 years and I’ve been doing a lot of crashing. It hasn’t felt like “well” for a long time.
Forgive me, I know I’m talking to myself here just to hear how it sounds, and feel how it feels, but it’s helping.
I want to have energy. I don’t want to wait another year. The precious, potentially active months and years of my late middle age are ticking away as the interminable negotiations drag on.
Yes, maybe PBS approval will come by April. But who’s to say it won’t be triaged, with the supposedly “well” like me left out to prioritise the heavily fibrotic and cirrhotic? Which exact medications will be approved? Will I have the choice of say, Daclatasvir, or will only the better researched drugs get approval?
And when, eventually, it is approved, it will almost certainly not be completely free. I paid over $400 for the PBS approved Interferon + Ribavirin + Boceprevir a couple of years ago (70 something dollars per script, once per month for 6 months). Will the newer drugs have a larger gap even when PBS approved? Perhaps the financial difference with the buyers club isn’t as great as might be assumed.
Anyway, all of this is from the part of me that doesn’t want to wait. There are other parts…
I think we should take seriously the possibility that fixhepc.com and/or the associated Buyers Club may be shut down by a pharma legal attack.
I am downloading all the key info from this site that would enable me to do it on my own if this site is shut down.
I relapsed after Boceprevir + Ribavirin + interferon a couple of years ago. I am G1. My problem was white & red blood cells dropping dangerously low resulted in lowering of dose. I’ve been worried about what resistance might have developed ever since, so I’ll be closely following this topic. Here’s something I just found that’s rather hopeful:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961994/ This study includes the following paragraph [Note DCV = Daclatasvir]:
“A combination of DCV and a nucleotide analogue inhibitor of HCV RNA-dependent RNA polymerase, sofosbuvir, with or without ribavirin for 24 wk achieved SVR in 100% of untreated HCV genotype 1a and 1b patients (n = 44) as well as in HCV genotype 1a and 1b patients (n = 41) who failed to respond to prior treatment with telaprevir or boceprevir, peginterferon and ribavirin. SVR was achieved in 93% of patients infected with HCV genotypes 2 and 3 (n = 44)[89,90].”
41 patients who failed telaprevir and boceprevir must surely have included people with resistant varieties. Interesting that the excellent result was achieved both with and without Ribavirin.