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  • in reply to: Soy an inducer of CYP3A4 ? #25640
    ratus
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    @ratus

    i was reading that i found interesting (not directly concern HepC but a lot of interested point about CYP 3A4)
    for exemple

    Other Herbals: CYP2D6 and CYP3A4 Activity
    Other CYP3A4 inhibitors include Chamomile extracts and tea39, Serenoa repens (Saw palmetto)40, as well as other herbals and spices such as sage, thyme, cloves, the soybean components daidzein and genistein41, pergamottin (active component of grapefruit juice) and glabridin42 (active component of licorice extracts and teas). ]

    http://home.earthlink.net/~ckaniklidis/interactions.htm#DrugHerb

    in reply to: Soy an inducer of CYP3A4 ? #25639
    ratus
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    @ratus

    one point is the succes of the treatment seems not different by country
    some people eats/drinks a lot of inducers (coffee,green tea,soy,etc..
    some others inhibitors like furocoumarins
    that furocoumarins are found in large quantities in many fruits and vegetables such as parsley, celery, dill, carrot, chervil, fennel, coriander, cumin, lime, pomelo, bitter orange, bergamot, mandarin , Lemon and many others

    so same conclusion

    A good varied diet – not eating the same stuff day after day – is a good way to avoid interactions (known or unknown) as well as being a pretty good way to eat.

    i agree and i think
    maybe it’s better to take treatment with a light dinner (i mean light in furocoumarin,omega 3 ,…etc)

    in reply to: Soy an inducer of CYP3A4 ? #25629
    ratus
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    @ratus

    well searching about i found some studies about soy (it’s also about ginseng but that was not the related topic

    https://www.ncbi.nlm.nih.gov/pubmed/12817527

    To determine if soy extract or Panax ginseng increases the urinary excretion of the 6-β-hydroxycortisol/cortisol ratio as a marker of cytochrome P450 (CYP) 3A enzyme induction, subjects received a soy extract containing 50 mg isoflavones twice daily (n = 20) or Panax ginseng 100 mg standardized to 4% ginsenosides twice daily (n = 20) for 14 days. Neither Panax ginseng nor soy extract significantly altered the urinary 6-β-OH-cortisol/cortisol ratio, suggesting that unlike St. John’s wort, they are not CYP3A inducers. Studies in vitro using human liver microsomes were performed to determine the effect of soy extract on probe substrates of CYP and UDP glucuronosyltransferase (UGT). Unhydrolyzed soy extract produced very little inhibition of CYP1A2, CYP2A6, and CYP2D6 and a trend of activation of CYP3A4. Hydrolyzed soy extract showed inhibition of all of the CYPs tested, particularly CYP2C9 and CYP3A4. UGT2B15 was the only UGT significantly inhibited. Even though both soy extract and ginseng have been shown to activate CYP3A4 in vitro, there is a lack of an in vitro correlation with the in vivo effects.

    then

    http://medicinalplants.us/herb-drug-interactions-soya

    About Soy fermented natto ( different from miso ..)

    Experimental evidence
    Experiments in animals to investigate the clinical observations for natto found that natto strongly antagonised the effects of warfarin.In one in vitro metabolism study in human liver microsomes,hydrolysed soya extract inhibited all of the cytochrome P450 isoenzymes tested, particularly CYP2C9 and CYP3A4 (which are responsible for the metabolism of warfarin). This suggests that an increased warfarin effect might have been expected, but the authors point out there is a lack of concordance between in vitro and in vivo findings.

    in reply to: Caffeine, codeine, noni not good with daclatasvir? #25497
    ratus
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    @ratus

    hello
    i was serching about herbs and CYP3A4
    i found that page wich seems interesting
    exemple for garlic

    Garlic (Allium sativum)
    Garlic ( Allium sativum L., Fam. Alliaceae) is used in
    modern phytotherapy to treat hypercholesterolaemia and
    prevent arteriosclerosis although the clinical evidence is
    far from compelling [2, 3] . Garlic preparations include
    garlic powder standardized to contain 1.3% alliin and
    0.6% allicin, garlic aged extract, which does not contain
    allicin but is high in water soluble phytochemicals, such
    as diallyl sulphides and garlic oil (i.e. essential oil obtained
    from the distillation of the cloves) [4] .
    Two garlic preparations, namely garlic oil and garlic
    powder, have been evaluated for their potential to affect
    CYP enzymes in clinical trials. The results suggest that
    garlic oil may selectively inhibit CYP2E1, but not other
    CYP isoforms (such as CYP1A2, CYP3A4 or CYP2D6)
    and that garlic powder has no effect on CYP3A4 [54–58] .
    Recently, it has been shown that a 21-day garlic treatment
    (aged garlic extract) induces intestinal expression of
    P-glycoprotein without aff

    avalaible on web or pdf
    Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data
    or pdf
    https://www.karger.com/Article/Pdf/334488

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