I spoke with a compounding herbalist who advised to use a filler of similar granularity to the daclatasvir. Since contacting James about this subject earlier today i came up with another method in which I fill the caps with filler first, then tip it out and weigh it, then work out how much dac per number of caps (in my case a 50 cap machine would need 3g dac for the 50 caps = 60mg/cap), then take the weight of the dac from the filler (e.g: 10g filler for 50 caps would equate to 7g filler + 3g dac ) then mix it up thoroughly, so I can fill the caps half full and be confident that each has the required 60mg. Though I finally understand the process above!
Am even thinking of using turmeric or beetroot powder so I know it’s all well mixed by the colour!
Huge thanks James for posting this, as everyone has likely heard that the compounding pharmacy professional association has put out an alert we may be asking them to manufacture our capsules and that “purity and efficacy cannot be guaranteed ” when sourcing generics from OS. Ho hum.
