We currently have very little data regarding possible drug interactions associated with marijuana use; however, based on our knowledge of the metabolism of the major cannabinoids it contains, we can theorize about possible interactions not yet studied. Side effects can be observed with agents such as cytochrome of all kinds. As for using Epclusa with marijuana, having personally tried it, I can say that there is no change. I buy medical marijuana from an old friend who has built a business on it. As I understand it, you can use it with the parsl.co platform, the purpose of which is to track the movement of cannabis products and related financial activity.