UpdateThis page is now getting a bit old. Since it was written literally thousands of patients have treated with generics, and the results have been presented at the EASL International Liver Congress in Barcelona in April 2016. Here are some useful links:
What does it mean to be Hepatitis C free?The new line of antiviral medications based on sofosbuvir, ledipasvir and daclatasvir molecules is very successful in curing Hepatitis C patients. But what does actually mean to be Hepatitis C free, in medical terms? Here is a short insight into a sustained virological response (SVR) and a medical treatment data of two patients who successfully underwent treatment with sofosbuvir-based medications and experience positive results.
Sustained Virological Response (SVR)Medically, Hepatitis C disease is associated with the presence of Hepatitis C virus (HCV). When a doctor finds signs of HCV infesting the liver via a blood sample, he or she can diagnose the patient in question is Hepatitis C positive. Such testing is usually necessary because Hepatitis C regularly does not manifest in very recognizable symptoms - we call it an asymptomatic disease, and people can live a normal life for 10 or 20 years before even realizing they have Hepatitis C.
The primary goal of HCV therapy is to cure the infection. Oxford Journals define sustained virological response (SVR) as undetectable HCV RNA 12 weeks (SVR12) or 24 weeks (SVR24) after treatment completion. The infection is cured in more than 99% of patients who achieve an SVR. The SVR is generally associated with resolution of liver disease in patients without cirrhosis. Patients with cirrhosis remain at risk of life-threatening complications; however hepatic fibrosis may regress and the risk of complications such as hepatic failure and portal hypertension is reduced. More data is required to ascertain the lifetime residual risk of hepatocellular carcinoma after viral infection has been eradicated. - http://files.easl.eu/easl-recommendations-on-treatment-of-hepatitis-C.pdf
Hepatitis C recurrenceUsually the number one concern of an ex-Hepatitis C patient is that the disease will somehow resurface. In medical world, it is not unusual for serious diseases such as cancer to be vanquished only to return again. Nonetheless, with the current Hepatitis C treatment regimen, the probability of Hepatitis C recurrence is minimized. According to study published by Oxford Journals, who analysed SVR durability, the 'incidence of late relapse is extremely low (<1%)'. This means that less than 1% of ex-Hepatitis C patient will be struck by the same disease again. In short, Hepatitis C, if treated correctly with sofosbuvir-based medications, has a minimal chance of recurrence.
How come Hepatitis C treatment is so efficient?Researching about Hepatitis C treatments, you will notice that Hepatitis C is always being treated with two or more active ingredients such as sofosbuvir, ledipasvir, daclatasvir, ribavirin and so on. The treatment regimen is specifically designed to eliminate 100% of Hepatitis C virus from your body.
While the newly discovered antiviral molecule sofosbuvir is extremely efficient at eliminating HCV, and can eliminate even 99.99% of the virus, the remaining 0.01% of the remaining virus can over time build up again. This would cause a relapse and Hepatitis C would resurge again. A second antiviral molecule (like for example ledipasvir in Harvoni) is added to the treatment to eliminate all the remaining viruses sofosbuvir was potentially unable to take care of. Both active molecules or drugs have a specific mechanism of action - they fight and eliminate HCV in different ways - and this is why the viruses that could not be eliminated by mechanism of action of sofosbuvir are readily eliminated by mechanism of action of ledipasvir or other appropriate antiviral molecule. In this way, 100% elimination is achieved and there is a negligible fear of Hepatitis C reoccurrence.
Hepatitis C patients success stories
Patient 1 - Cured of Hepatitis C in 4 weeks for less than $2,000This is a proof of success of Hepatitis C treatment. The patient's details are of confidential nature. However, we can reveal that Patient 1 was bein treated under supervision of Dr. James Freeman and the medications used were supplied by Chinese manufacturer. All in all, the treatment that would ordinarily cost more than $80,000 in Australia was reduced to less than $2,000, and what is the most important - the results of being treated with supplied Chinese medication were the same as with the originators medicines.
As you can clearly see, Patient 1 started treatment with sofosbuvir-based regimen on 7th of July 2015. He was Pos* (found positive for Hepatitis C) based on HCVL RNA viral load. The second blood sample was taken on 4th of August 2015, after only 4 weeks of treatment. Results show Neg result (No HCV RNA was detected in patient's blood). This is a proof that after only 4 weeks Hepatitis C patients can be cured of Hepatitis C.
Here is another testament of just how successful sofosbuvir-based treatment supplied by Chinese manufacturers is. Patient 2 was treated with the same Hepatitis C treatment regimen and was cured in about 1 month.
As you can see, Patient 2 started treatment on 21st of July 2015. After less than a month on 19th of August 2016, we see that no HCV was detected in patient's bloodwork.
Click here to find out how to get the same results.