Home › Forums › Main Forum › Experts Corner › To treat or not to treat: Acute HCV mono-infection
- This topic has 9 replies, 7 voices, and was last updated 9 years ago by
sabrecat.
-
AuthorPosts
-
25 March 2016 at 1:26 am #14422
Hi Looking4Help,
Thank you for posting! What a story! I have never seen ALT/AST numbers like those before. Are you still alive to read this?
Nearly everyone on this site has chronique Hep-C, not acute Hep-C.
Correction… Many of the people on this site USED TO HAVE chronique Hep-C. Now more and more are being cured with generic DAAs (Sof+Dac or Sof+Led), with very few side effects (me included – and absolutely no sides).
Before the days of DAAs, the usual advice was “wait and see”. But this was mainly because the classic Interferon+ribavarin treatment was expensive, horrible for many, and had only a moderate success rate.
Maybe you will clear the virus naturally… But you will only know that in 6 to 9 months time. Why wait and suffer? My advice is find out what your genotype is, get a sympathetic Dr to write a prescription, and order your generic treatment right now. There is lots of advice on here on how to do it. Most people on this site report VL < 15 or even UND after around 4 weeks. You can do it all on-line for about $1000, more or less, from a reputable source (again, check out the various threads about this). Cheers,
Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).25 March 2016 at 3:29 am #14424I had read that ALT/AST could reach several thousand in acute infections but never seen an example previously.
The good news is that your LFT now all seem to be tracking downwards and your VL is currently low.
Clearance of Hep C of any genotype by any means does not appear to confer immunity due to the HCV virus’ ready ability to mutate allowing it to avoid your immune system.
Chronic HCV tends to be a slow acting and seemingly benign disease as seen by the number of us who did not become aware of infection until decades later. Having said that, it is causing damage the whole time you are infected so I would advise that earlier treatment of the chronic form is preferable to waiting but I’m not sure how well that translates to acute infection.
Below are the current AADSL/IDSA recommendations regarding Management of Acute HCV Infection.
http://www.hcvguidelines.org/full-report/management-acute-hcv-infection
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
25 March 2016 at 3:42 am #14426You have a 25% chance of clearing virus yourself in the next 6 months and you are past the worst.
With medication you have a 95%+ chance and you will be virus free within about 4 weeks and you only need 8 weeks treatment.
It’s your choice. Waiting won’t kill you but you can get better sooner and chances are you WILL have to treat.
YMMV
25 March 2016 at 11:41 am #14449Looking4Help wrote:3. Aside from taking care of myself, eating well and sleeping well etc, is there anything that I can do to increase my chances of spontaneously clearing the virus?
4. ]Any other thoughts etc?Since sustained hyperresponsiveness of dendritic cells is associated with spontaneous resolution of acute hepatitis C, then I’m going to say a good option would be pre/probiotics.
Since HCV core protein is a pro-inflammatory TLR2 ligand; (this allows the immune system to recognise the virus and respond appropriately.) Chronic infection means that the virus has managed to subvert these responses. So supplying TLR2 ligands may be a way of switching back on the responses the virus has managed to subvert. So I’m going to say…spirulina. 4 out of 30 patients cleared the virus with spirulina in this trial
http://www.biomedcentral.com/1471-230X/12/32
And since hep c is glucose dependent, a low carb diet can also help.
P.
25 March 2016 at 5:14 pm #14462Price wrote:Looking4Help wrote:3. Aside from taking care of myself, eating well and sleeping well etc, is there anything that I can do to increase my chances of spontaneously clearing the virus?
4. ]Any other thoughts etc?Since sustained hyperresponsiveness of dendritic cells is associated with spontaneous resolution of acute hepatitis C, then I’m going to say a good option would be pre/probiotics.
Since HCV core protein is a pro-inflammatory TLR2 ligand; (this allows the immune system to recognise the virus and respond appropriately.) Chronic infection means that the virus has managed to subvert these responses. So supplying TLR2 ligands may be a way of switching back on the responses the virus has managed to subvert. So I’m going to say…spirulina. 4 out of 30 patients cleared the virus with spirulina in this trial
http://www.biomedcentral.com/1471-230X/12/32
And since hep c is glucose dependent, a low carb diet can also help.
P.[/quote]
Price, You clearly don’t have a clue of what you are talking about – no informed person would quote such specific details from isolated papers chosen out of context and use that information to give treatment advice.
Your behaviour is ignorant and deceptive. Fortunately in this case, your directions are essentially harmless (apart from the spurious low-carb recommendation), but I sincerely recommend staying away from playing the expert on medical topics of which you know less than nothing.
You could hurt someone one day.
G4, F4, cirrhosis.
Thank you to Gilead, Michael Sofia, and the terrific folk at FixHepC for making this adventure possible.
YEAR….. ALT….. AST….. GGT… FERRITIN………………………………….
2009……. 210….. 215….. 953….. 1400……….. (Bad health, stupidity)
2015……. 60……. 45……. 150….. 360…………. (Improved diet and health, FixHepC treatment)
2016……. 20……. 24……. 25……. 156…………. (SVR 12)25 March 2016 at 8:24 pm #14464Actually Al, Dr Robert Gish, one of the top hepatologists in the US thinks it’s a great answer and so do the docs at Research Gate where we had the same discussion and since I spent 2 years studying this subject as well as pre/probiotics, I can quote papers until the cows come home. It’s not my fault you only understand Kincaid 8.
If you want to challenge what I say you may try quoting a few papers yourself because your answers are always the same and they are BORING nonsense. It’s going to take more than one little troll to prove me wrong, I can tell you that.
“The potential use of Toll-like receptor agonists to restore the dysfunctional immunity induced by hepatitis C virus”
http://www.sciencedirect.com/science/article/pii/S000887491000064X
Price
29 March 2016 at 5:31 am #14599Hi Price,
“And since hep c is glucose dependent, a low carb diet can also help”.
I am into 5 months of Sof/Dac: at EOT, is it worth steering clear of too much sugar in my (occasional) coffee?
Just saw a post on a relapse an starting again yesterday and want to give my my body the best chance of getting rid of any stragglers that are left post treatment.
J.
1 April 2016 at 12:34 pm #14733Sure but it also depends on what else you’re eating.
3 April 2016 at 1:48 pm #14809Price wrote:Sure but it also depends on what else you’re eating.
Thanks Price,
a timely reminder for me as over the now 23 weeks of treatment my new found energy found me eating things I would know to steer clear of – and hence a suspension in weight loss. Now back on the straight and narrow food wise.
Yours
J
-
AuthorPosts
- You must be logged in to reply to this topic.