Are you asking if anyone has done more than 24 weeks treatment Michael?

I’m GT1a, did 12 weeks Sofo/Led and now doing 12 weeks Sofo/Dac, but I’m not sure if I’ve heard of anyone doing 36 weeks.

My very best wishes for your successful treatment this time, I can’t imagine how 4 failed treatments must have felt and my heart goes out to you. You must be a strong one to deal with all that! Still, a whole new approach with this treatment hey – and looking very good for you at <12 4 weeks & now UND : +1: How long do you have to go?

Ah apologies, brain-fog moment.

I can understand how your friend feels really wanting to do all she can this time around.
So, she has done 21 weeks Sofo/Led and is doing another 12 Sofo/Led on top? That’s a long treatment period, maybe her liver is complaining regarding the amount of meds? but this is only a thought, with the Riba too, it must have been tough on her system.

All I can offer is my own experience which is I did Sofo/Led for 12 and am now in the next 12 with Sofo/DAC – I am also GT1a but treatment naive. What I can tell you, is that since I have changed to Sofo/Dac I feel much better and re-energised, it is only instinct and feeling better that tells me this medicine suits me better, so not a fact. It could be an absorption issue, or possibly genetic RAVS but on researching those, I don’t seem to fit the picture as many seem to be connected with fatty liver etc and I am the opposite, I don’t seem to absorb fat .properly. It’s complex. There are some people who have issues with Sofo/Led from what I have read. Nearly all advise is geared towards fatty liver and very little regarding the opposite. Did your friend lose weight pre tx ? has weight-loss been an issue for her at any point? I started to put on a little weight during treatment with Sofo/Led and have a huge appetite on the Sofo/Dac – Just want to eat all the time! Really, I guess we don’t really know why this happens, but can try small adjustments to address the issue. I am told there are less aborption issues with Sofo/Dac.

I was also advised to take Digestive enzymes – I take them the opposite end of the day to Sofo/Dac with my main meal, I feel these have really helped, but again, it’s just a feeling and not a fact.

During treatment I got a chest infection and had to take antibiotics, a course of probiotics (taken again at the opposite end of the day to the meds) may have corrected something or other and I felt they really helped me too. I believe Riba can upset the digestive system, stomach area, maybe she could get advise on these things? I read somewhere on Twitter just yesterday (so a new thing) that antibiotics can mess up the absorption of medicines and are particularly not recommended on the Abbvie treatments (but could they also affect other treatments too?) . Did your friend have to take antibiotics at any point?

Well, I can only offer small things that may or may not help, but may be of interest. to your friend. I wish her every success this time around, please let me know how she progresses and send her all my best.

lg

Hi Michael, Just picked up the form from GP for next VL test, hopefully early next week to check out the latest. I must confess to having some nerves

Will post as soon as ……

to those who treated before
I pray also that this works for you

Also geno 1a stage 4-lifetime non responder-finally cleared on sovaldi-olysio,relapsed.Did 24 weeks of just harvoni after that,cleared,relapsed.Now im finishing month 3 of 4 months of Zepatier and ribavirin.NUmbers are very good except I cant clear.1st bloodwork I went down to 18,0000 and 2nd bloodwork showed quantification went up to 32,000.Frustrating part is the numbers will go right back up to the roof once I stop and I cant qualify for any trials because my platelets get too low and my bilirubin gets too high.My family needs me,I would sell my soul to find the right medication.

Ya, I’m not a doctor, but I gotta agree with tweakmax … Zepatier is an NS5A inhibitor paired with an NS3/4A protease inhibitor … so should maybe have an NS5B inhibitor to make it fully effective.

Edit: I repeat that I’m not a doctor … and I haven’t memorized the RAVs and their specific drug relationships, but if by chance your RAVs are related to Sofosbuvir resistance, you might check to see if they are also resistant to Dasabuvir.

And you might want to check this thread:
http://fixhepc.com/forum/daa-access/471-mesochem-apis-of-sof-dac-led.html

Hi Michael,

How is your friend doing?

I was UND between 2-4 weeks on the Sofo/Dac. Dr Freeman recommended I add Sunprevir for 4 weeks towards EOT. I’m waiting on VL result taken at 24 weeks. Feeling rather ‘drugged’ but very manageable. I do hope your friend listens to the advise from Dr F on this site and hope all is well with her.

LG