Hi Neil, welcome to the forum. Yes, hundreds here, likely thousands of people have successfully used the Indian generics.
First these points … The meds from Mylan are the equivalent of the branded drugs. All of the Indian Sofosbuvir, Ledipasvir, and/or Daclatasvir producers are in fact having their medicines manufactured by either Hetero or Natco and they are all proving equally effective. The unlicensed drugs from the companies in Bangladesh are also being shown to be equal in effectiveness, and it is almost certain that the drugs coming from Morocco, Algeria and Pakistan are as well, although we don’t have the data on those last three yet. In a couple months the results from 1,000,000 people that have been treated in Egypt with mostly Egyptian generics will be presented and the preliminary data indicate that again they are the equivalent of the branded drugs.
So the question of quality, branded vs generic, should not be your concern.
The issue your doctor is worried about is your genotype and your treatment experience. G3 treatment experienced people are having a harder time reaching SVR (sustained virologic response.) Additionally, people with higher levels of fibrosis/cirrhosis have a harder time getting the medicine into the scarred areas of their livers, where the virus can hide and then reappear after treatment. In such cases, it is generally advised to either lengthen treatment, change drugs, or add more drugs … maybe ribivirin, maybe an NS3 inhibitor … or two/three of these options.
You haven’t told us your fibroscan score or viral load or any other blood test numbers, so it’s going to be difficult to tell you whether you would be best served to simply lengthen treatment or add more meds/different meds. But our doctor here, Dr. James Freeman, is one of the top world authorities on this issue, so if you put your further data here in this thread he can probably answer your questions.
And if it turns out you should be taking Epclusa, (Sofosbuvir/Velpatasvir,) Beacon Pharmaceuticals in Bangladesh is already selling a generic form of this combination called Sofosvel. Beacon has provided meds for many, many people here and you can find their contact info in the top post of their thread in the Pharmas Market section of the forum … or click here:
http://fixhepc.com/forum/daa-access/439-beacon-pharmaceuticals-sof-dac-sof-dac-sof-vel-combo.html
Again, welcome to the forum.
Edit: It might also be helpful to know where you live on the planet.
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