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  • 6 May 2017 at 3:37 pm #25992
    Avatar photomgalbrai
    • Guardian Angel
    • ★★★★★
    @mgalbrai

    Hi,
    I am sorry for your suffering, however, you appear to be more the exception than the rule.
    Side effects occur with all drugs, usually in direct proportion to its potency. Harvoni is one very potent medication, as anything that eradicates HCV would have to be. It was brought to market to end suffering and save lives. It succeeded.
    We are ALL participants in the long term effects of DAA “clinical trial.”
    Harvoni gave me my life back and I never experienced a single side effect.
    Good Luck!
    m

    Curehcvnow@gmail.com
    http://forums.delphiforums.com/generichcvtx

    G 1a F-1
    Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
    11/17/15 4 wk lab ALT 17 AST 16 <15
    11/18/15 Started Harvoni
    12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
    1/14/16 Fin. Tx
    7/07/16 UND SVR 24

    7 May 2017 at 5:51 am #25994
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi CHRISMR2,

    Thanks for your post and sorry to hear about your troubles.

    Certainly auto-immune stuff is common with HCV (pre-treatment) and possibly not solved by SVR. Cryo-globulinaemia is something to get looked at.

    The forum here is open and censored only for SPAM. As you can see there are about 3000 members and for most people the post-treatment results are good, as in the vast majority of patients report being better. Part of the reason I wanted such a thing to exist was to flag things that might be going under the radar.

    One of the things I tell people recurrently is that for a group of patients of average age 55 all the other things related to ageing happen to patients with HCV (treated or not) at the same (or higher rates) than the general population.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735500/

    My personal view is that the combination of Sofosbuvir + Daclatasvir is cleaner than Harvoni (with respect to on treatment side effects), and probably has a slightly higher cure rate. The nature of the trials, focussing on cure/not-cured to keep the costs manageable does not provide the statistical power to say that with certainty, but it is my gut feeling.

    Your post will stay here for other people to chip in their comments about their personal experience.

    Hope things settle down for you and make sure you get thoroughly checked out.

    YMMV

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