Home › Forums › Main Forum › Patient Stories › SVR › Does Intraocular pressure (IOP) decline after SVR?

Viewing 5 posts - 1 through 5 (of 5 total)
  • Author
    Posts
  • 11 September 2018 at 3:41 am #28536
    beahavan
    • Topics: 5
    • Replies: 81
    • Total: 86
    • Guardian Angel
    • ★★★★★
    @beahavan

    I have not been able to find any studies that show that the higher Intraocular pressure (IOP) associated with HCV declines after SVR.

    Has this been anyone experience?

    G4
    F0-F1
    diagnosed in 2006
    Tx naive
    Treatment started 8/12/16, Ledipasvir/ Sofosbuvir (Harvoni) supplied by Monkmed
    8/1/16 ALT 36 AST 40
    1/4/17 ALT 17 AST 21
    7/13/17 ALT 17 AST 25
    12/28/17 ALT 22 AST26
    2/22/18 ALT 19 AST 25
    7/10/18 ALT 26 AST 32
    1/8/19 ALT 16 AST 28
    7/2/19 ALT 16 AST 26
    Hcv Rna, Quantitative Real Time Pcr <15 NOT DETECTED (IU/mL) NOT DETECTED

    11 September 2018 at 2:01 pm #28537
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I can find the before, but not the after.

    Patients with HCV are known to have higher Intra Occular Pressure (IOP) and other issues. IOP is measured with tonometry:

    https://www.ncbi.nlm.nih.gov/pubmed/23470265

    RESULTS:
    HCV-infected patients presented an almost four times higher risk of lacrimal function involvement by tear break-up time [odds ratio (OR)=3.76; 95% confidence interval (CI) 1.75-8.04, P=0.001] and Schirmer’s test (OR=4.17; 95% CI 1.83-9.50, P=0.001) than the controls. The chances of palpebral biomicroscopic lesions (blepharitis) were also higher (OR=3.21; 95% CI 1.49-6.94, P=0.003). Mean tonometry was higher in HCV patients (right eye 14.4±2.3 vs. 12.2±1.5, P<0.001 and left eye 14.5±2.3 vs. 12.0±1.4, P<0.001).

    YMMV

    11 September 2018 at 5:35 pm #28541
    beahavan
    • Topics: 5
    • Replies: 81
    • Total: 86
    • Guardian Angel
    • ★★★★★
    @beahavan

    Yes unfortunately data on the effect of sustained virological response (SVR) on the risk of EHMs are limited. Nothing yet on IOP.

    Thank you Dr James.

    G4
    F0-F1
    diagnosed in 2006
    Tx naive
    Treatment started 8/12/16, Ledipasvir/ Sofosbuvir (Harvoni) supplied by Monkmed
    8/1/16 ALT 36 AST 40
    1/4/17 ALT 17 AST 21
    7/13/17 ALT 17 AST 25
    12/28/17 ALT 22 AST26
    2/22/18 ALT 19 AST 25
    7/10/18 ALT 26 AST 32
    1/8/19 ALT 16 AST 28
    7/2/19 ALT 16 AST 26
    Hcv Rna, Quantitative Real Time Pcr <15 NOT DETECTED (IU/mL) NOT DETECTED

    15 September 2018 at 10:30 pm #28552
    beahavan
    • Topics: 5
    • Replies: 81
    • Total: 86
    • Guardian Angel
    • ★★★★★
    @beahavan

    IOP 2015 Right 16 Left 16
    IOP 2018 Right 17 Left 16

    So no decrease after treatment in my case.

    G4
    F0-F1
    diagnosed in 2006
    Tx naive
    Treatment started 8/12/16, Ledipasvir/ Sofosbuvir (Harvoni) supplied by Monkmed
    8/1/16 ALT 36 AST 40
    1/4/17 ALT 17 AST 21
    7/13/17 ALT 17 AST 25
    12/28/17 ALT 22 AST26
    2/22/18 ALT 19 AST 25
    7/10/18 ALT 26 AST 32
    1/8/19 ALT 16 AST 28
    7/2/19 ALT 16 AST 26
    Hcv Rna, Quantitative Real Time Pcr <15 NOT DETECTED (IU/mL) NOT DETECTED

    16 September 2018 at 3:21 am #28553
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Thanks for the info beahavan.

    With the normal range being around 11-21 that looks like being somethjng to keep an eye on rather than panic about

    YMMV

  • Author
    Posts
Viewing 5 posts - 1 through 5 (of 5 total)
  • You must be logged in to reply to this topic.