Good News for Cirrhotic Patients - FixHepC

This topic has 2 replies, 2 voices, and was last updated 9 years ago by klhilde.

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19 November 2015 at 9:53 am #4222
klhilde
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- Guardian Angel
@klhilde
http://www.empr.com/aasld-2015/sofosbuvir-based-therapy-leads-to-rapid-loxl2-decline-in-cirrhosis/article/453762/

Maybe Dr. Freeman will explain this in plain English.
19 November 2015 at 3:39 pm #4242
Dr James
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- Guardian Angel
@fixhepc
It says get rid of Hep C using drugs and the chemical mediator LOXL2 that causes fibrosis also goes away.

Which explains why we see regression of fibrosis at VL=0 and SVR.

If you are F4 you will probably never regain F0 and SVR, but you may well be less F’d than currently so regression back to F3 or F2.

Improvements in fibroscan scores post cure are well documented

http://fixhepc.com/forum/experts-corner/106-liver-cirrhosis-does-not-disappear-in-12-weeks.html

This explains the underlying pathophysiology.

YMMV
20 November 2015 at 9:41 am #4271
klhilde
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@klhilde
I’m guessing you mean “never regain F0 at SVR”

“less F’d”
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