This article says, ” Sofosbuvir, like many drugs, is partially cleared via the p-glycoprotein transporter (P-GP) system. Amiodarone is a known inhibitor of P-GP transport. Decreased P-GP activity means patients taking amiodarone could be exposed to higher levels of sofosbuvir. ”
And I think it’s worse when you use both Sof+Dac. 5 out of the 9 patients that had cardiac problems while on Amiodarone were also taking Sof+Dac.
“Could the HCV Drug Sofosbuvir Be Cardiotoxic?”
http://www.medscape.com/viewarticle/842315#vp_1
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