Home › Forums › Main Forum › Experts Corner › Viral Load and SVR › Do not worry Detected or Undetected if below LLoQ

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  • 19 January 2016 at 2:23 pm #9801
    Avatar photoAriel
    • Guardian Angel
    • ★★★★★
    @ariel

    I am confused…I was just grazing the internet, despite knowing that can be a risk, and MedicineNet.com stated that ‘achieving an SVR is NOT a CURE” !!!!!!! Pardon? …please can I have medical feedback. I thought an SVR meant cured. I am so confused, how can achieving an SVR not equate to a cure? Is this a lexical semantic or what….comments please :)

    19 January 2016 at 2:27 pm #9803
    Avatar photoEnkel
    • Guardian Angel
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    @enkel

    SVR maybe not but SVR12 is a cure 99% SVR24 is almost 99.9

    Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
    Started Twinvir 12/12/15.
    Two weeks
    ALT 17 at 2 weeks
    Viral Load UND at 2 weeks
    ALT 13.5 at 7 weeks EOT
    ALT 10.5 at 15 weeks EOT
    ALT 13 at 27 weeks EOT, VL UND, Cured

    19 January 2016 at 3:29 pm #9816
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    Yep, as you say……and Enkel also in a different way, it is semantics. They can’t give a 100% guarantee that you have got rid of the virus 24 weeks post treatment (or even 240 or 2400 weeks) so they are not prepared to call it “cured” but rather a “sustained” response. To you and me it is cured!!! :)

    But wait…..the same website you quote also has a definition of “cure” that would seem to include what we experience during SVR.

    “Cure: 1. To heal, to make well, to restore to good health. 2. A time without recurrence of a disease so that the risk of recurrence is small.”

    http://www.medicinenet.com/script/main/art.asp?articlekey=31243

    Methinks they are having a dollar each way. :evil:

    It comes down to what Abraham Lincoln said about not trusting what you read on the Internet. :whistle:

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    21 January 2016 at 4:35 pm #10003
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    At SVR4 there is a 96% chance you never have detectable virus again
    At SVR12 it is 99%
    At SVR24 it is 99.9%

    So if the HCV is not back within 6 months of EOT you have a 1000:1 chance of never seeing it again, and going on to die of ripe old age.

    Personally I’d call that cured.

    YMMV

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